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    VCP valosin containing protein [ Homo sapiens (human) ]

    Gene ID: 7415, updated on 4-Jan-2025

    Summary

    Official Symbol
    VCPprovided by HGNC
    Official Full Name
    valosin containing proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12666
    See related
    Ensembl:ENSG00000165280 MIM:601023; AllianceGenome:HGNC:12666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p97; TERA; CDC48; FTDALS6
    Summary
    This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See VCP in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35056064..35072625, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35075243..35091804, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35056061..35072622, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily G member 1 Neighboring gene RNA, 7SL, cytoplasmic 338, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28319 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35078961-35079568 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:35079644-35079809 Neighboring gene FA complementation group G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35080785-35081391 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28320 Neighboring gene PIGO antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with VCP; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with valosin containing protein (VCP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpu vpu A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation PubMed
    vpu The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: FANCG

    Clone Names

    • MGC8560, MGC131997, MGC148092

    Gene Ontology Provided by GOA

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ADP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity PubMed 
    enables ATP hydrolysis activity PubMed 
    enables ATP hydrolysis activity PubMed 
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables BAT3 complex binding PubMed 
    enables DNA clamp loader activity  
    enables K48-linked polyubiquitin modification-dependent protein binding PubMed 
    enables MHC class I protein binding  
    enables RNA binding PubMed 
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables deubiquitinase activator activity PubMed 
    enables identical protein binding PubMed 
    enables lipid binding  
    enables polyubiquitin modification-dependent protein binding  
    enables polyubiquitin modification-dependent protein binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein phosphatase binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin-like protein ligase binding PubMed 
    enables ubiquitin-modified protein reader activity PubMed 
    enables ubiquitin-specific protease binding PubMed 
    Items 1 - 25 of 27
    Items 1 - 25 of 63
    Process Evidence Code Pubs
    involved_in ATP metabolic process  
    involved_in DNA damage response PubMed 
    involved_in DNA repair PubMed 
    involved_in ERAD pathway PubMed 
    involved_in ERAD pathway PubMed 
    involved_in ERAD pathway  
    involved_in ERAD pathway PubMed 
    involved_in NADH metabolic process PubMed 
    involved_in aggresome assembly  
    involved_in autophagosome maturation  
    involved_in autophagosome maturation PubMed 
    involved_in autophagy PubMed 
    involved_in cellular response to arsenite ion PubMed 
    involved_in cellular response to heat PubMed 
    involved_in cellular response to misfolded protein PubMed 
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in cytoplasm protein quality control PubMed 
    involved_in double-strand break repair PubMed 
    involved_in endoplasmic reticulum stress-induced pre-emptive quality control PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in endosome to lysosome transport via multivesicular body sorting pathway PubMed 
    involved_in establishment of protein localization PubMed 
    involved_in flavin adenine dinucleotide catabolic process PubMed 
    involved_in interstrand cross-link repair  
    involved_in macroautophagy PubMed 
    involved_in mitotic spindle disassembly  
    involved_in negative regulation of hippo signaling PubMed 
    involved_in negative regulation of protein localization to chromatin PubMed 
    involved_in negative regulation of smoothened signaling pathway PubMed 
    involved_in positive regulation of ATP biosynthetic process PubMed 
    involved_in positive regulation of Lys63-specific deubiquitinase activity PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of mitochondrial membrane potential PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of oxidative phosphorylation PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein K63-linked deubiquitination PubMed 
    involved_in positive regulation of protein catabolic process PubMed 
    involved_in positive regulation of protein-containing complex assembly PubMed 
    involved_in proteasomal protein catabolic process PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in protein ubiquitination PubMed 
    involved_in protein ubiquitination PubMed 
    involved_in protein-DNA covalent cross-linking repair PubMed 
    involved_in regulation of aerobic respiration PubMed 
    involved_in regulation of apoptotic process PubMed 
    involved_in regulation of protein localization to chromatin PubMed 
    involved_in regulation of synapse organization  
    involved_in retrograde protein transport, ER to cytosol  
    involved_in retrograde protein transport, ER to cytosol PubMed 
    involved_in retrograde protein transport, ER to cytosol PubMed 
    involved_in retrograde protein transport, ER to cytosol  
    involved_in stress granule disassembly PubMed 
    involved_in stress granule disassembly PubMed 
    involved_in translesion synthesis PubMed 
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    involved_in viral genome replication PubMed 
    Items 1 - 25 of 63
    Items 1 - 20 of 37
    Component Evidence Code Pubs
    part_of ATPase complex  
    part_of Derlin-1 retrotranslocation complex PubMed 
    part_of VCP-NPL4-UFD1 AAA ATPase complex  
    part_of VCP-NPL4-UFD1 AAA ATPase complex PubMed 
    part_of VCP-NPL4-UFD1 AAA ATPase complex  
    part_of VCP-NPL4-UFD1 AAA ATPase complex PubMed 
    part_of VCP-NSFL1C complex PubMed 
    part_of VCP-NSFL1C complex  
    located_in azurophil granule lumen  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasmic stress granule PubMed 
    is_active_in cytosol  
    located_in cytosol PubMed 
    is_active_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    located_in ficolin-1-rich granule lumen  
    located_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in lipid droplet PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    part_of proteasome complex PubMed 
    part_of protein-containing complex PubMed 
    located_in secretory granule lumen  
    located_in site of double-strand break PubMed 
    Items 1 - 20 of 37

    General protein information

    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    TER ATPase
    NP_001341856.1
    NP_001341857.1
    NP_009057.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007887.1 RefSeqGene

      Range
      5001..21675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_657

    mRNA and Protein(s)

    1. NM_001354927.2 → NP_001341856.1  transitional endoplasmic reticulum ATPase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353795, BU689324
      Consensus CDS
      CCDS94403.1
      UniProtKB/TrEMBL
      A0A7P0T8A3, C9IZA5, C9JUP7
      Related
      ENSP00000392088.2, ENST00000448530.6
      Conserved Domains (1) summary
      TIGR01243
      Location:1 → 719
      CDC48; AAA family ATPase, CDC48 subfamily
    2. NM_001354928.2 → NP_001341857.1  transitional endoplasmic reticulum ATPase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353795, BU689324
      Consensus CDS
      CCDS94403.1
      UniProtKB/TrEMBL
      A0A7P0T8A3, C9IZA5, C9JUP7
      Related
      ENSP00000399456.2, ENST00000417448.2
      Conserved Domains (1) summary
      TIGR01243
      Location:1 → 719
      CDC48; AAA family ATPase, CDC48 subfamily
    3. NM_007126.5 → NP_009057.1  transitional endoplasmic reticulum ATPase isoform 1

      See identical proteins and their annotated locations for NP_009057.1

      Status: REVIEWED

      Source sequence(s)
      BC007562, BC110913, BU689324, DA880782
      Consensus CDS
      CCDS6573.1
      UniProtKB/Swiss-Prot
      B2R5T8, P55072, Q0V924, Q2TAI5, Q969G7, Q9UCD5, V9HW80
      UniProtKB/TrEMBL
      A0A7I2V540
      Related
      ENSP00000351777.6, ENST00000358901.11
      Conserved Domains (1) summary
      TIGR01243
      Location:25 → 764
      CDC48; AAA family ATPase, CDC48 subfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      35056064..35072625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      35075243..35091804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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