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    Rars1 arginyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 104458, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rars1provided by MGI
    Official Full Name
    arginyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:1914297
    See related
    Ensembl:ENSMUSG00000018848 AllianceGenome:MGI:1914297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rars; 2610011N19Rik; 2610037E21Rik
    Summary
    Enables arginine-tRNA ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 41.2), CNS E11.5 (RPKM 34.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rars1 in Genome Data Viewer
    Location:
    11 A4; 11 21.96 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35699207..35725355, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (35808381..35834528, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene microRNA 103-1 Neighboring gene STARR-seq mESC enhancer starr_29194 Neighboring gene pantothenate kinase 3 Neighboring gene fibrillarin-like 1 Neighboring gene STARR-seq mESC enhancer starr_29197 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene teneurin transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article
    2. Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Cakir Z, et al. Mol Cell Proteomics, 2023 May. PMID 37019383, Free PMC Article
    3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arginine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arginine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arginine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arginyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arginine--tRNA ligase, cytoplasmic
    Names
    argRS
    arginyl-tRNA synthetase, cytoplasmic
    NP_080212.2
    XP_036012095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025936.3 → NP_080212.2  arginine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_080212.2

      Status: VALIDATED

      Source sequence(s)
      AK076160, CB523934, CF748175
      Consensus CDS
      CCDS24544.1
      UniProtKB/Swiss-Prot
      Q3THP2, Q3TM73, Q3U8R2, Q3U930, Q5SXA8, Q8VDW1, Q9D0I9
      Related
      ENSMUSP00000018992.4, ENSMUST00000018992.4
      Conserved Domains (4) summary
      cd00671
      Location:193 → 457
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      smart01016
      Location:79 → 166
      Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
      PLN02286
      Location:80 → 660
      PLN02286; arginine-tRNA ligase
      cl12020
      Location:498 → 660
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      35699207..35725355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156202.1 → XP_036012095.1  arginine--tRNA ligase, cytoplasmic isoform X1

      Conserved Domains (1) summary
      PLN02286
      Location:8 → 588
      PLN02286; arginine-tRNA ligase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0I9.2 GenPept UniProtKB/Swiss-Prot:Q9D0I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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