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    Akr1c13 aldo-keto reductase family 1, member C13 [ Mus musculus (house mouse) ]

    Gene ID: 27384, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Akr1c13provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member C13provided by MGI
    Primary source
    MGI:MGI:1351662
    See related
    Ensembl:ENSMUSG00000021213 AllianceGenome:MGI:1351662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4014
    Summary
    Predicted to enable several functions, including ketosteroid monooxygenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including cellular response to jasmonic acid stimulus; glycoside metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within xenobiotic metabolic process. Predicted to be active in cytosol. Is expressed in gut and liver lobe. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E18 (RPKM 17.2), large intestine adult (RPKM 12.8) and 17 other tissues See more
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    Genomic context

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    See Akr1c13 in Genome Data Viewer
    Location:
    13 A1; 13 2.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4241167..4255601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4191168..4205604)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C18 Neighboring gene STARR-seq mESC enhancer starr_33499 Neighboring gene STARR-seq mESC enhancer starr_33500 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33502 Neighboring gene nuclear encoded tRNA lysine 6 (anticodon CTT) Neighboring gene aldo-keto reductase family 1, member C19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread. McFarland AP, et al. mBio, 2018 May 15. PMID 29764944, Free PMC Article
    2. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. McFarland AP, et al. Immunity, 2017 Mar 21. PMID 28329705, Free PMC Article
    3. Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis. Endo S, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17888864
    4. Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach. Ikeda S, et al. FEBS Lett, 1999 Oct 15. PMID 10526179
    5. Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Shimizu R, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33348080

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Listeria monocytogenes secretion of c-di-AMP inhibits RECON ( Akr1c13) activity, drives augmented NF-kappaB activation and nitric oxide production, and ultimately enhances intercellular spread.
      Title: RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.
    2. Akr1c13 functions as a cytosolic sensor for bacterial cyclic dinucleotides, shaping inflammatory gene activation
      Title: Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.
    3. analysis of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases.
      Title: Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4014

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chlordecone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to jasmonic acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member C13
    Names
    aldo-keto reductase AKR1C13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426627.1 → NP_001413556.1  aldo-keto reductase family 1 member C13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121097, AC122840
      UniProtKB/TrEMBL
      Q54A37

    2. NM_001426630.1 → NP_001413559.1  aldo-keto reductase family 1 member C13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121097, AC122840
      UniProtKB/TrEMBL
      Q54A37

    3. NM_013778.3 → NP_038806.2  aldo-keto reductase family 1 member C13 isoform 1

      See identical proteins and their annotated locations for NP_038806.2

      Status: VALIDATED

      Source sequence(s)
      AC121097, AC122840
      Consensus CDS
      CCDS26220.1
      UniProtKB/Swiss-Prot
      Q8VC28, Q9D7R9, Q9R0M9
      UniProtKB/TrEMBL
      Q54A37
      Related
      ENSMUSP00000021634.3, ENSMUST00000021634.4
      Conserved Domains (2) summary
      COG0656
      Location:8 → 307
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      4241167..4255601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC28.2 GenPept UniProtKB/Swiss-Prot:Q8VC28

    Gene LinkOut

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