Ace2 angiotensin converting enzyme 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ace2provided by MGI
Official Full Name: angiotensin converting enzyme 2provided by MGI
Primary source: MGI:MGI:1917258
See related: Ensembl:ENSMUSG00000015405 AllianceGenome:MGI:1917258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010305L05Rik
Summary: Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 49.9), small intestine adult (RPKM 19.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.12 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (162922338..162971414)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164139342..164188418)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE2 Knockout Mice Are Resistant to High-Fat Diet-Induced Obesity in an Age-Dependent Manner.
Title: ACE2 Knockout Mice Are Resistant to High-Fat Diet-Induced Obesity in an Age-Dependent Manner.
ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway.
Title: ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway.
Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach.
Title: Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach.
Integrated analysis of gut microbiome and its metabolites in ACE2-knockout and ACE2-overexpressed mice.
Title: Integrated analysis of gut microbiome and its metabolites in ACE2-knockout and ACE2-overexpressed mice.
The role of ACE2 in RAS axis on microglia activation in Parkinson's disease.
Title: The role of ACE2 in RAS axis on microglia activation in Parkinson's disease.
Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2.
Title: Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2.
ACE2 Expressed on Myeloid Cells Alleviates Sepsis-Induced Acute Liver Injury via the Ang-(1-7)-Mas Receptor Axis.
Title: ACE2 Expressed on Myeloid Cells Alleviates Sepsis-Induced Acute Liver Injury via the Ang-(1-7)-Mas Receptor Axis.
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection.
Title: FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection.
Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
Title: Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
Title: ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.

Submit: New GeneRIF Correction See all GeneRIFs (180)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (46) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE098785 (e-PCR)
- UniSTS:245294

Ace2 (e-PCR), detects polymorphism
- UniSTS:545882

Ace2 (e-PCR), detects polymorphism
- UniSTS:499073

D1S2869 (e-PCR), detects polymorphism
- UniSTS:47827

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables carboxypeptidase activity	TAS Traceable Author Statement more info	PubMed
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiotensin maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in angiotensin maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiotensin maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-mediated drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-mediated drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in entry receptor-mediated virion attachment to host cell	IEA Inferred from Electronic Annotation more info
involved_in entry receptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-proline import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gap junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: angiotensin-converting enzyme 2

Names: ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2

NP_001123985.1

EC 3.4.17.23

NP_081562.2

EC 3.4.17.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130513.1 → NP_001123985.1 angiotensin-converting enzyme 2 precursor

See identical proteins and their annotated locations for NP_001123985.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AK141604, BY722909

Consensus CDS

CCDS30518.1

UniProtKB/Swiss-Prot

Q8R0I0, Q99N70, Q99N71

UniProtKB/TrEMBL

C7ECU2, Q3URC9

Related

ENSMUSP00000107890.4, ENSMUST00000112271.10

Conserved Domains (2) summary

pfam01401
Location:21 → 606

Peptidase_M2; Angiotensin-converting enzyme

pfam16959
Location:617 → 770

Collectrin; Renal amino acid transporter
NM_027286.4 → NP_081562.2 angiotensin-converting enzyme 2 precursor

See identical proteins and their annotated locations for NP_081562.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AI115946, AK141604

Consensus CDS

CCDS30518.1

UniProtKB/Swiss-Prot

Q8R0I0, Q99N70, Q99N71

UniProtKB/TrEMBL

C7ECU2, Q3URC9

Related

ENSMUSP00000073626.5, ENSMUST00000073973.11

Conserved Domains (2) summary

pfam01401
Location:21 → 606

Peptidase_M2; Angiotensin-converting enzyme

pfam16959
Location:617 → 770

Collectrin; Renal amino acid transporter