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    Stx16 syntaxin 16 [ Mus musculus (house mouse) ]

    Gene ID: 228960, updated on 27-Nov-2024

    Summary

    Official Symbol
    Stx16provided by MGI
    Official Full Name
    syntaxin 16provided by MGI
    Primary source
    MGI:MGI:1923396
    See related
    Ensembl:ENSMUSG00000027522 AllianceGenome:MGI:1923396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syn16; 4930401D03; 5430410K23Rik; 6330500A18Rik
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; connective tissue; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 23.8), CNS E11.5 (RPKM 23.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stx16 in Genome Data Viewer
    Location:
    2 H4; 2 97.85 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173918052..173941564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174076260..174099771)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30143 Neighboring gene vesicle-associated membrane protein 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7892 Neighboring gene aminopeptidase-like 1 Neighboring gene predicted gene 10714

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endocytic recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102423.1NP_001095893.1  syntaxin-16 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC095989, BP763202, BY122006, CX123636
      UniProtKB/TrEMBL
      Q0VGN4
      Conserved Domains (2) summary
      cd15845
      Location:230288
      SNARE_syntaxin16; SNARE motif of syntaxin 16
      cl00143
      Location:76190
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    2. NM_001102424.1NP_001095894.1  syntaxin-16 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC094436, BC095989, BP763202, BY122006
      UniProtKB/TrEMBL
      Q0VGN4
      Conserved Domains (2) summary
      cd15845
      Location:217275
      SNARE_syntaxin16; SNARE motif of syntaxin 16
      cl00143
      Location:63177
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    3. NM_001102425.1NP_001095895.1  syntaxin-16 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC095989, BP763202, BY125296
      UniProtKB/TrEMBL
      Q0VGN4
      Conserved Domains (2) summary
      cd15845
      Location:213271
      SNARE_syntaxin16; SNARE motif of syntaxin 16
      cl00143
      Location:59173
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    4. NM_001363029.1NP_001349958.1  syntaxin-16 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL669896
      UniProtKB/TrEMBL
      F7CJY7
      Related
      ENSMUSP00000116618.2, ENSMUST00000156054.2
      Conserved Domains (2) summary
      cl22856
      Location:217244
      SNARE; SNARE motif
      cl26014
      Location:73254
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    5. NM_001363030.1NP_001349959.1  syntaxin-16 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK029571, AL669896
      UniProtKB/TrEMBL
      Q0VGN4, Q8C0W8
      Conserved Domains (2) summary
      COG5325
      Location:20249
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:181239
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    6. NM_001363031.1NP_001349960.1  syntaxin-16 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL669896
      Conserved Domains (2) summary
      COG5325
      Location:19186
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:118176
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    7. NM_172675.4NP_766263.2  syntaxin-16 isoform a

      See identical proteins and their annotated locations for NP_766263.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC095989, BP763202, BY122006
      Consensus CDS
      CCDS17147.2
      UniProtKB/Swiss-Prot
      A2ACM7, Q8BVI5
      UniProtKB/TrEMBL
      Q0VGN4
      Related
      ENSMUSP00000085218.4, ENSMUST00000087908.10
      Conserved Domains (2) summary
      cd15845
      Location:234292
      SNARE_syntaxin16; SNARE motif of syntaxin 16
      cl00143
      Location:80194
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

    RNA

    1. NR_156433.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL669896

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173918052..173941564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499440.5XP_006499503.1  syntaxin-16 isoform X2

      Conserved Domains (2) summary
      COG5325
      Location:19186
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:118176
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    2. XM_030250767.2XP_030106627.1  syntaxin-16 isoform X2

      Conserved Domains (2) summary
      COG5325
      Location:19186
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:118176
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    3. XM_030250772.2XP_030106632.1  syntaxin-16 isoform X2

      Conserved Domains (2) summary
      COG5325
      Location:19186
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:118176
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    4. XM_006499437.4XP_006499500.1  syntaxin-16 isoform X1

      See identical proteins and their annotated locations for XP_006499500.1

      UniProtKB/TrEMBL
      Q0VGN4, Q8C0W8
      Conserved Domains (2) summary
      COG5325
      Location:20249
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:181239
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    5. XM_006499439.4XP_006499502.1  syntaxin-16 isoform X1

      See identical proteins and their annotated locations for XP_006499502.1

      UniProtKB/TrEMBL
      Q0VGN4, Q8C0W8
      Conserved Domains (2) summary
      COG5325
      Location:20249
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:181239
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    6. XM_006499436.4XP_006499499.1  syntaxin-16 isoform X1

      See identical proteins and their annotated locations for XP_006499499.1

      UniProtKB/TrEMBL
      Q0VGN4, Q8C0W8
      Conserved Domains (2) summary
      COG5325
      Location:20249
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:181239
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    7. XM_006499438.4XP_006499501.1  syntaxin-16 isoform X1

      See identical proteins and their annotated locations for XP_006499501.1

      UniProtKB/TrEMBL
      Q0VGN4, Q8C0W8
      Conserved Domains (2) summary
      COG5325
      Location:20249
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:181239
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    8. XM_030250771.1XP_030106631.1  syntaxin-16 isoform X2

      Conserved Domains (2) summary
      COG5325
      Location:19186
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:118176
      SNARE_syntaxin16; SNARE motif of syntaxin 16