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    Tent4a terminal nucleotidyltransferase 4A [ Mus musculus (house mouse) ]

    Gene ID: 210106, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tent4aprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 4Aprovided by MGI
    Primary source
    MGI:MGI:2682295
    See related
    Ensembl:ENSMUSG00000034575 AllianceGenome:MGI:2682295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POLK; Pols; TRF4; LAK-1; Papd7; TRF4-1
    Summary
    Predicted to enable guanylyltransferase activity and poly(A) RNA polymerase activity. Predicted to be involved in RNA metabolic process; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tent4a in Genome Data Viewer
    Location:
    13 B3; 13 35.55 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69646071..69682710, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69497952..69534236, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35444 Neighboring gene STARR-seq mESC enhancer starr_34935 Neighboring gene predicted gene, 35514 Neighboring gene STARR-seq mESC enhancer starr_34936 Neighboring gene STARR-seq mESC enhancer starr_34937 Neighboring gene RIKEN cDNA A930018O16 gene Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2004 Aug. PMID 15329828
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC69673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3' uridylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal nucleotidyltransferase 4A
    Names
    DNA polymerase sigma
    PAP associated domain containing 7
    PAP-associated domain-containing protein 7
    TRAMP-like complex polyadenylate polymerase
    non-canonical poly(A) RNA polymerase PAPD7
    polymerase (DNA directed) sigma
    terminal guanylyltransferase
    NP_001162602.2
    NP_941002.3
    XP_006517250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169131.2 → NP_001162602.2  terminal nucleotidyltransferase 4A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122484

    2. NM_198600.3 → NP_941002.3  terminal nucleotidyltransferase 4A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122484
      Consensus CDS
      CCDS26622.1
      UniProtKB/Swiss-Prot
      A0A0G2JDV2, G3X948, Q6PB75
      Related
      ENSMUSP00000142516.2, ENSMUST00000198607.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      69646071..69682710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517187.2 → XP_006517250.1  terminal nucleotidyltransferase 4A isoform X1

      Conserved Domains (1) summary
      COG5260
      Location:233 → 538
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PB75.3 GenPept UniProtKB/Swiss-Prot:Q6PB75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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