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    Tubb1 tubulin, beta 1 class VI [ Mus musculus (house mouse) ]

    Gene ID: 545486, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tubb1provided by MGI
    Official Full Name
    tubulin, beta 1 class VIprovided by MGI
    Primary source
    MGI:MGI:107814
    See related
    Ensembl:ENSMUSG00000016255 AllianceGenome:MGI:107814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M(beta)1; 2810484G07Rik
    Summary
    A structural constituent of cytoskeleton. Involved in several processes, including platelet aggregation; platelet formation; and thyroid hormone transport. Acts upstream of or within spindle assembly. Located in microtubule. Is expressed in dorsal root ganglion; liver; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant macrothrombocytopenia TUBB1-related. Orthologous to human TUBB1 (tubulin beta 1 class VI). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 21.1), liver E14 (RPKM 14.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tubb1 in Genome Data Viewer
    Location:
    2 H4; 2 97.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (174292388..174300173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174450595..174458380)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member C/D, Th1l Neighboring gene cathepsin Z Neighboring gene STARR-positive B cell enhancer ABC_E6030 Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_06641 Neighboring gene ATP synthase F1 subunit epsilon Neighboring gene PRELI domain containing 3B Neighboring gene STARR-positive B cell enhancer ABC_E6031

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule-based process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thyroid hormone transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080971.2NP_001074440.1  tubulin beta-1 chain

      See identical proteins and their annotated locations for NP_001074440.1

      Status: VALIDATED

      Source sequence(s)
      AL844534
      Consensus CDS
      CCDS38359.1
      UniProtKB/Swiss-Prot
      A2AQ07
      Related
      ENSMUSP00000016399.6, ENSMUST00000016399.6
      Conserved Domains (2) summary
      PTZ00010
      Location:1428
      PTZ00010; tubulin beta chain; Provisional
      cd02187
      Location:2426
      beta_tubulin; The beta-tubulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      174292388..174300173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)