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    Vapb vesicle-associated membrane protein, associated protein B and C [ Mus musculus (house mouse) ]

    Gene ID: 56491, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vapbprovided by MGI
    Official Full Name
    vesicle-associated membrane protein, associated protein B and Cprovided by MGI
    Primary source
    MGI:MGI:1928744
    See related
    Ensembl:ENSMUSG00000054455 AllianceGenome:MGI:1928744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VAP-B; VAMP-B; VAP33b; D2Abb2e; Vamp33b
    Summary
    Predicted to enable several functions, including FFAT motif binding activity; protein dimerization activity; and tubulin binding activity. Predicted to be involved in several processes, including IRE1-mediated unfolded protein response; endoplasmic reticulum organization; and modulation by host of viral genome replication. Located in membrane. Is expressed in dorsal root ganglion. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 12.3), bladder adult (RPKM 11.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vapb in Genome Data Viewer
    Location:
    2 H4; 2 97.37 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173579378..173626132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173737571..173784336)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB22A, member RAS oncogene family Neighboring gene microRNA 6340 Neighboring gene RIKEN cDNA 1700010B08 gene Neighboring gene STARR-positive B cell enhancer ABC_E1610 Neighboring gene adenomatosis polyposis coli down-regulated 1 pseudogene Neighboring gene predicted gene 14371 Neighboring gene STARR-seq mESC enhancer starr_06629 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173682567-173682768 Neighboring gene predicted gene, 30017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FFAT motif binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IRE1-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modulation by host of viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation by virus of viral protein levels in host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein-associated protein B
    Names
    VAMP-associated protein 33b
    VAMP-associated protein B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019806.6NP_062780.2  vesicle-associated membrane protein-associated protein B

      See identical proteins and their annotated locations for NP_062780.2

      Status: VALIDATED

      Source sequence(s)
      AL844849, AL845503
      Consensus CDS
      CCDS17146.1
      UniProtKB/Swiss-Prot
      Q9QY76
      UniProtKB/TrEMBL
      Q8BH80
      Related
      ENSMUSP00000064699.5, ENSMUST00000067530.6
      Conserved Domains (1) summary
      pfam00635
      Location:8111
      Motile_Sperm; MSP (Major sperm protein) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173579378..173626132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)