Sf1 splicing factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sf1provided by MGI
Official Full Name: splicing factor 1provided by MGI
Primary source: MGI:MGI:1095403
See related: Ensembl:ENSMUSG00000024949 AllianceGenome:MGI:1095403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BBP; MZFM; WBP4; Zfp162
Summary: Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: SF1 (Gene ID: 22668) and NR5A1 (Gene ID: 26423) share the SF1 symbol/alias in common. SF1 is a widely used alternative name for nuclear receptor subfamily 5 group A member 1 (NR5A1), which can be confused with the official symbol for SF1 (splicing factor 1). [30 Mar 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 49.7), adrenal adult (RPKM 41.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.48 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6413952..6428060)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6363673..6378038)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sf1 SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone)
Title: Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
we found that KLF6 transcriptionally cooperates with NUR77 and SF1
Title: KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression.
Title: Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.
Results clearly indicate that SF-1 is involved in the regulation of LIPE expression after activation of protein kinase A in adrenocortical cells.
Title: SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells.
SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development.
Title: Involvement of SF-1 in neurogenesis and neuronal migration in the developing neocortex.
SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
Title: SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
Data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis.
Title: Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis indicates the involvement of SF1 in the beta-catenin-mediated regulation of proliferation.
Title: Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN56392 (e-PCR)
- UniSTS:381192

BB094781 (e-PCR)
- UniSTS:186138

ECD00774 (e-PCR)
- UniSTS:281883

stSG635675 (e-PCR)
- UniSTS:460856

Sf1 (e-PCR), detects polymorphism
- UniSTS:479034

ECD02238 (e-PCR)
- UniSTS:283338

REN56367 (e-PCR)
- UniSTS:381167

REN56368 (e-PCR)
- UniSTS:381168

REN56369 (e-PCR)
- UniSTS:381169

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	IGI Inferred from Genetic Interaction more info
involved_in mRNA splicing, via spliceosome	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within male sex determination	IGI Inferred from Genetic Interaction more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of steroid biosynthetic process	IGI Inferred from Genetic Interaction more info

Component	Evidence Code	Pubs
part_of U2AF complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: splicing factor 1

Names: mammalian branch point-binding protein; transcription factor ZFM1; zinc finger gene in MEN1 locus; zinc finger protein 162

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110791.2 → NP_001104261.1 splicing factor 1 isoform 1

See identical proteins and their annotated locations for NP_001104261.1

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

Consensus CDS

CCDS50368.1

UniProtKB/TrEMBL

Q3UI45, Q3UK67

Related

ENSMUSP00000121309.2, ENSMUST00000131252.8

Conserved Domains (2) summary

smart00343
Location:278 → 293

ZnF_C2HC; zinc finger

COG5176
Location:17 → 257

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
NM_001360393.2 → NP_001347322.1 splicing factor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

Conserved Domains (1) summary

cl25681
Location:29 → 211

SF1-HH; Splicing factor 1 helix-hairpin domain
NM_001403434.1 → NP_001390363.1 splicing factor 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403435.1 → NP_001390364.1 splicing factor 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403436.1 → NP_001390365.1 splicing factor 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403439.1 → NP_001390368.1 splicing factor 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403440.1 → NP_001390369.1 splicing factor 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

UniProtKB/TrEMBL

D3YZC9

Related

ENSMUSP00000109117.2, ENSMUST00000113489.8
NM_001403441.1 → NP_001390370.1 splicing factor 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403442.1 → NP_001390371.1 splicing factor 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403443.1 → NP_001390372.1 splicing factor 1 isoform 12

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403444.1 → NP_001390373.1 splicing factor 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403445.1 → NP_001390374.1 splicing factor 1 isoform 13

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

Conserved Domains (2) summary

smart00343
Location:278 → 293

ZnF_C2HC; zinc finger

COG5176
Location:17 → 257

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
NM_001403446.1 → NP_001390375.1 splicing factor 1 isoform 14

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403447.1 → NP_001390376.1 splicing factor 1 isoform 15

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403448.1 → NP_001390377.1 splicing factor 1 isoform 16

Status: VALIDATED

Source sequence(s)

AC127556, AC167245
NM_001403449.1 → NP_001390378.1 splicing factor 1 isoform 17

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

UniProtKB/TrEMBL

D3YZD0

Related

ENSMUSP00000109116.2, ENSMUST00000113488.8
NM_011750.3 → NP_035880.2 splicing factor 1 isoform 2

See identical proteins and their annotated locations for NP_035880.2

Status: VALIDATED

Source sequence(s)

AC127556, AC167245

Consensus CDS

CCDS50369.1

UniProtKB/TrEMBL

E9Q4Q2, Q3TZI3

Related

ENSMUSP00000109115.2, ENSMUST00000113487.8

Conserved Domains (2) summary

smart00343
Location:278 → 293

ZnF_C2HC; zinc finger

COG5176
Location:17 → 257

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]