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    ETP1 Etp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ETP1
    Official Full Name
    Etp1p
    Primary source
    SGD:S000001002
    Locus tag
    YHL010C
    See related
    AllianceGenome:SGD:S000001002; FungiDB:YHL010C; VEuPathDB:YHL010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nuclear localization sequence binding activity and ubiquitin binding activity. Involved in response to ethanol. Predicted to be active in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ETP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (81964..83721, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene ribose phosphate diphosphokinase subunit PRS3 Neighboring gene Yap3p Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Reyes-Turcu FE, et al. Cell, 2006 Mar 24. PMID 16564012
    2. ETP1/YHL010c is a novel gene needed for the adaptation of Saccharomyces cerevisiae to ethanol. Snowdon C, et al. FEMS Yeast Res, 2009 May. PMID 19416103
    3. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. Li S, et al. J Biol Chem, 1998 Mar 13. PMID 9497340
    4. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae. Comyn SA, et al. Sci Rep, 2017 Jun 23. PMID 28646136, Free PMC Article
    5. Isolation and mapping of self-assembling protein domains encoded by the Saccharomyces cerevisiae genome using lambda repressor fusions. Mariño-Ramírez L, et al. Yeast, 2002 May. PMID 11967834, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Etp1p
    NP_011853.1
    • hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      81964..83721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179090.1 → NP_011853.1  TPA: Etp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKQ3, P38748, Q6Q5F9
      UniProtKB/TrEMBL
      G2WF57
      Conserved Domains (4) summary
      COG1196
      Location:409 → 534
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16457
      Location:238 → 281
      RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
      pfam02148
      Location:301 → 363
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cd12717
      Location:114 → 201
      RRM_ETP1; RNA recognition motif (RRM) found in yeast RING finger protein ETP1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38748.1

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