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    ATG36 Atg36p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG36
    Official Full Name
    Atg36p
    Primary source
    SGD:S000003721
    Locus tag
    YJL185C
    See related
    AllianceGenome:SGD:S000003721; FungiDB:YJL185C; VEuPathDB:YJL185C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitophagy and pexophagy. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG36 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (82095..82976, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tyrosine protein kinase SWE1 Neighboring gene alpha-1,2-mannosyltransferase MNN5 Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit GON7 Neighboring gene alpha-1,6-mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Peroxisomal PTS1-Import Defect of PEX1- Deficient Cells Is Independent of Pexophagy in Saccharomyces cerevisiae. Mastalski T, et al. Int J Mol Sci, 2020 Jan 29. PMID 32013259, Free PMC Article
    2. Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker's Yeast. Gerke J, et al. Front Bioeng Biotechnol, 2020. PMID 33102464, Free PMC Article
    3. Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation. Meguro S, et al. J Biol Chem, 2020 Nov 27. PMID 32958557, Free PMC Article
    4. The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle. Boniewska-Bernacka E, et al. Acta Biochim Pol, 2006. PMID 17146497
    5. Vac8 determines phagophore assembly site vacuolar localization during nitrogen starvation-induced autophagy. Gatica D, et al. Autophagy, 2021 Jul. PMID 32508216, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation.
      Title: Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation.
    2. It was concluded that Pex3 recruits the pexophagy receptor Atg36. This reinforces the pivotal role played by Pex3 in coordinating the size of the peroxisome pool, and establishes its role in pexophagy in S. cerevisiae.
      Title: Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae.
    3. the contribution of the ER24 gene product Ylr376Cp and of the two suppressor gene products Yjl185Cp and Yjr129Cp to a complex regulation of the glyoxylate cycle in yea
      Title: The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg36p
    NP_012350.1
    • Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      82095..82976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181618.1 → NP_012350.1  TPA: Atg36p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW05, P46983
      UniProtKB/TrEMBL
      A6ZQF0, B3LPU1, N1P8Y5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46983.1

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