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    DGR2 Dgr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DGR2
    Official Full Name
    Dgr2p
    Primary source
    SGD:S000001604
    Locus tag
    YKL121W
    See related
    AllianceGenome:SGD:S000001604; FungiDB:YKL121W; VEuPathDB:YKL121W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DGR2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (214142..216700)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ssh4p Neighboring gene signal recognition particle subunit SRP21 Neighboring gene Oac1p Neighboring gene Vph2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones. Colleaux L, et al. Yeast, 1992 Apr. PMID 1514329
    2. TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae. Topolska M, et al. Biomolecules, 2020 Nov 25. PMID 33255682, Free PMC Article
    3. Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. Murley A, et al. J Cell Biol, 2017 Sep 4. PMID 28774891, Free PMC Article
    4. Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Watanabe M, et al. Curr Genet, 2009 Aug. PMID 19466415
    5. A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Ralser M, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19004802, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Dgr2p
    NP_012801.1
    • hypothetical protein; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      214142..216700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179687.1 → NP_012801.1  TPA: Dgr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXG9, P32330
      UniProtKB/TrEMBL
      B3LQX7, N1P166
      Conserved Domains (2) summary
      sd00039
      Location:176 → 238
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:173 → 506
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32330.1

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