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    FPR2 peptidylprolyl isomerase family protein FPR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852131, updated on 27-Dec-2024

    Summary

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    Official Symbol
    FPR2
    Official Full Name
    peptidylprolyl isomerase family protein FPR2
    Primary source
    SGD:S000002927
    Locus tag
    YDR519W
    See related
    AllianceGenome:SGD:S000002927; FungiDB:YDR519W; VEuPathDB:YDR519W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FKB2
    Summary
    Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and regulation of transcription by RNA polymerase II. Located in membrane. Used to study Huntington's disease. Orthologous to several human genes including FKBP2 (FKBP prolyl isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FPR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1480425..1480832)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Grh1p Neighboring gene protein disulfide isomerase EUG1 Neighboring gene Urc2p Neighboring gene Sps2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. Partaledis JA, et al. Yeast, 1992 Aug. PMID 1279908
    2. The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Partaledis JA, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 7685904, Free PMC Article
    3. Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. Nielsen JB, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1380159, Free PMC Article
    4. A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. Benton BM, et al. J Cell Biol, 1994 Nov. PMID 7525596, Free PMC Article
    5. Purification of FKBP-70, a novel immunophilin from Saccharomyces cerevisiae, and cloning of its structural gene, FPR3. Manning-Krieg UC, et al. FEBS Lett, 1994 Sep 19. PMID 7925954

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FK506 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    peptidylprolyl isomerase family protein FPR2
    NP_010807.3
    • Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1480425..1480832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180827.3 → NP_010807.3  TPA: peptidylprolyl isomerase family protein FPR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010807.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTE0, P32472
      UniProtKB/TrEMBL
      A6ZZA6, B3LFF1, C8Z675, G2WBP6, N1P7I4
      Conserved Domains (1) summary
      COG0545
      Location:39 → 132
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32472.1

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