EKI1 bifunctional choline kinase/ethanolamine kinase EKI1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EKI1
Official Full Name: bifunctional choline kinase/ethanolamine kinase EKI1
Primary source: SGD:S000002554
Locus tag: YDR147W
See related: AllianceGenome:SGD:S000002554; FungiDB:YDR147W; VEuPathDB:YDR147W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables choline kinase activity and ethanolamine kinase activity. Involved in phosphatidylcholine biosynthetic process and phosphatidylethanolamine biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to several human genes including CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EKI1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (751631..753235)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zinc-mediated regulation of ethanolamine kinase and the synthesis of phospholipids via the CDP-ethanolamine branch of the Kennedy pathway were controlled in part by Zap1p.
Title: Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables choline kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables choline kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables choline kinase activity	IEA Inferred from Electronic Annotation more info
enables choline kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ethanolamine kinase activity	IEA Inferred from Electronic Annotation more info
enables ethanolamine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ethanolamine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional choline kinase/ethanolamine kinase EKI1

NP_010431.3

EC 2.7.1.82

Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

751631..753235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180454.3 → NP_010431.3 TPA: bifunctional choline kinase/ethanolamine kinase EKI1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010431.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSD0, Q03764

UniProtKB/TrEMBL

B3LGD3, G2WAP7, N1P6E5

Conserved Domains (2) summary

cd05157
Location:135 → 508

ETNK_euk; Euykaryotic Ethanolamine kinase

pfam04428
Location:79 → 129

Choline_kin_N; Choline kinase N-terminus