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    dsc3 protein dsc3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541990, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dsc3
    Official Full Name
    protein dsc3
    Primary source
    PomBase:SPAC20H4.02
    Locus tag
    SPOM_SPAC20H4.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dsc3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2113990..2114930)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bromodomain-containing protein Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp5 Neighboring gene general transcription elongation factor TFIIS Neighboring gene ATP-dependent 3'-5'-directionality DNA helicase fml2 Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene ncRNA Neighboring gene Gpl1-Gih35-Wdr83 complex RNA-binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors. Burr R, et al. J Biol Chem, 2017 Mar 31. PMID 28202541, Free PMC Article
    2. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. Raychaudhuri S, et al. J Biol Chem, 2015 Jun 5. PMID 25918164, Free PMC Article
    3. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Chong R, et al. J Biol Chem, 2013 Jul 12. PMID 23729666, Free PMC Article
    4. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. Stewart EV, et al. J Biol Chem, 2012 Jan 2. PMID 22086920, Free PMC Article
    5. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. Lloyd SJ, et al. J Biol Chem, 2013 Jul 19. PMID 23760507, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsc E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Dsc E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein dsc3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2113990..2114930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019053.3 → NP_593622.1  protein dsc3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593622.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HE10
      Conserved Domains (2) summary
      pfam10302
      Location:9 → 99
      DUF2407; DUF2407 ubiquitin-like domain
      pfam13373
      Location:135 → 246
      DUF2407_C; DUF2407 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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