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    GYP6 GTPase-activating protein GYP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GYP6
    Official Full Name
    GTPase-activating protein GYP6
    Primary source
    SGD:S000003580
    Locus tag
    YJL044C
    See related
    AllianceGenome:SGD:S000003580; FungiDB:YJL044C; VEuPathDB:YJL044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in activation of GTPase activity. Located in endosome and trans-Golgi network. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GYP6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (358300..359676, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene succinate dehydrogenase SDH9 Neighboring gene uncharacterized protein Neighboring gene Mhp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Strom M, et al. Nature, 1993 Feb 25. PMID 8441469
    2. Biochemical characterization of Gyp6p, a Ypt/Rab-specific GTPase-activating protein from yeast. Will E, et al. J Biol Chem, 2001 Apr 13. PMID 11278907
    3. Inhibition of sodium/proton exchange by a Rab-GTPase-activating protein regulates endosomal traffic in yeast. Ali R, et al. J Biol Chem, 2004 Feb 6. PMID 14610088
    4. Structural and functional analysis of a novel coiled-coil protein involved in Ypt6 GTPase-regulated protein transport in yeast. Tsukada M, et al. Mol Biol Cell, 1999 Jan. PMID 9880327, Free PMC Article
    5. Rab GAP cascade regulates dynamics of Ypt6 in the Golgi traffic. Suda Y, et al. Proc Natl Acad Sci U S A, 2013 Nov 19. PMID 24194547, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein GYP6
    NP_012491.3
    • GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      358300..359676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181477.3 → NP_012491.3  TPA: GTPase-activating protein GYP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012491.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWE0, P32806
      UniProtKB/TrEMBL
      G2WGX4, N1P0W8
      Conserved Domains (1) summary
      smart00164
      Location:145 → 336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32806.2

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