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    NOP13 Nop13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855547, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NOP13
    Official Full Name
    Nop13p
    Primary source
    SGD:S000005119
    Locus tag
    YNL175C
    See related
    AllianceGenome:SGD:S000005119; FungiDB:YNL175C; VEuPathDB:YNL175C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in nucleolus. Part of preribosome. Orthologous to human RBM23 (RNA binding motif protein 23). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NOP13 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (307401..308612, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL22 Neighboring gene Tda7p Neighboring gene Mdg1p Neighboring gene anaphase promoting complex subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae. Wu K, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452019, Free PMC Article
    2. The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome. McCann KL, et al. Elife, 2016 Apr 14. PMID 27077951, Free PMC Article
    3. Puf6 primes 60S pre-ribosome nuclear export at low temperature. Gerhardy S, et al. Nat Commun, 2021 Aug 4. PMID 34349113, Free PMC Article
    4. Yvh1 is required for a late maturation step in the 60S biogenesis pathway. Kemmler S, et al. J Cell Biol, 2009 Sep 21. PMID 19797079, Free PMC Article
    5. Biochemical and genetic characterization of Yra1p in budding yeast. Kashyap AK, et al. Yeast, 2005 Jan 15. PMID 15584090

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nop13p
    NP_014224.2
    • Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      307401..308612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183013.2 → NP_014224.2  TPA: Nop13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014224.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W110, P53883
      UniProtKB/TrEMBL
      A6ZRR0, B3LP26, C7GTE9, C8ZG53, G2WLT3, N1P475
      Conserved Domains (2) summary
      cd12396
      Location:127 → 217
      RRM1_Nop13p_fungi; RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 13 (Nop13p) and similar proteins
      cd12397
      Location:241 → 316
      RRM2_Nop13p_fungi; RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 13 (Nop13p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53883.2

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