MDH2 malate dehydrogenase MDH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MDH2
Official Full Name: malate dehydrogenase MDH2
Primary source: SGD:S000005486
Locus tag: YOL126C
See related: AllianceGenome:SGD:S000005486; FungiDB:YOL126C; VEuPathDB:YOL126C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in gluconeogenesis and protein import into peroxisome matrix. Located in cytosol and nuclear periphery. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MDH2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (81787..82920, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast.
Title: A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast.
fructose-1,6-bisphosphatase and malate dehydrogenase degradation is mediated by distinct proteolytic pathways and signaling events
Title: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables L-malate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: malate dehydrogenase MDH2

NP_014515.2

EC 1.1.1.37

Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

81787..82920 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183380.1 → NP_014515.2 TPA: malate dehydrogenase MDH2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014515.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1U2, P22133

UniProtKB/TrEMBL

C7GV03, C8ZHJ0, N1NX84

Conserved Domains (1) summary

TIGR01772
Location:15 → 372

MDH_euk_gproteo; malate dehydrogenase, NAD-dependent