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    KTD1 DUP240 family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851280, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KTD1
    Official Full Name
    DUP240 family protein
    Primary source
    SGD:S000000076
    Locus tag
    YAR028W
    See related
    AllianceGenome:SGD:S000000076; FungiDB:YAR028W; VEuPathDB:YAR028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to toxic substance. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KTD1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (184892..185596)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene DUP240 family protein UIP3 Neighboring gene DUP240 family protein Neighboring gene pheromone-regulated DUP240 family protein PRM9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of a rapidly evolving yeast defense factor, KTD1, against the secreted killer toxin K28. Andreev I, et al. Proc Natl Acad Sci U S A, 2023 Feb 21. PMID 36800387, Free PMC Article
    2. Expansion and contraction of the DUP240 multigene family in Saccharomyces cerevisiae populations. Leh-Louis V, et al. Genetics, 2004 Aug. PMID 15342502, Free PMC Article
    3. Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability. Poirey R, et al. Microbiology (Reading), 2002 Jul. PMID 12101299
    4. Structural basis of V-ATPase V(O) region assembly by Vma12p, 21p, and 22p. Wang H, et al. Proc Natl Acad Sci U S A, 2023 Feb 7. PMID 36724250, Free PMC Article
    5. Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins. de Sousa GF, et al. PLoS One, 2015. PMID 26692264, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to toxic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUP240 family protein
    NP_009415.1
    • Killer toxin defense factor; key polymorphic factor in the defense against K28 toxin; localizes mainly to vacuolar membrane; most likely acts against K28 during its trafficking after endocytosis; member of DUP240 gene family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      184892..185596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178222.1 → NP_009415.1  TPA: DUP240 family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPN0, P39548
      UniProtKB/TrEMBL
      C7GTT5, N1P942, Q70CG4
      Conserved Domains (1) summary
      pfam00674
      Location:80 → 165
      DUP; DUP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39548.1

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