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    mak2 phosphorelay sensor kinase Mak2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mak2
    Official Full Name
    phosphorelay sensor kinase Mak2
    Primary source
    PomBase:SPAC27E2.09
    Locus tag
    SPOM_SPAC27E2.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    phk1
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    Genomic context

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    See mak2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4027019..4034337)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA replication factor C complex subunit Rfc3 Neighboring gene 40S ribosomal protein S0B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans. Maksimov V, et al. Curr Genet, 2017 May. PMID 27613427, Free PMC Article
    2. Two-component mediated peroxide sensing and signal transduction in fission yeast. Quinn J, et al. Antioxid Redox Signal, 2011 Jul 1. PMID 20919928
    3. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Buck V, et al. Mol Biol Cell, 2001 Feb. PMID 11179424, Free PMC Article
    4. Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe. Tan H, et al. FEMS Yeast Res, 2007 Sep. PMID 17559414
    5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate distinct functions for the three histidine kinases; Mak1 alone or Mak2 and Mak3 together were sufficient for the repression of the meiotic cycle when nutrients were available.
      Title: Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables heme binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables peroxide sensor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein histidine kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorelay sensor kinase Mak2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4027019..4034337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019841.3 → NP_594410.1  phosphorelay sensor kinase Mak2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594410.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14002
      Conserved Domains (10) summary
      smart00387
      Location:1866 → 1985
      HATPase_c; Histidine kinase-like ATPases
      smart00388
      Location:1754 → 1818
      HisKA; His Kinase A (phosphoacceptor) domain
      COG0784
      Location:2174 → 2303
      CheY; CheY chemotaxis protein or a CheY-like REC (receiver) domain [Signal transduction mechanisms]
      COG2202
      Location:1528 → 1744
      PAS; PAS domain [Signal transduction mechanisms]
      COG2203
      Location:1443 → 1603
      FhlA; GAF domain [Signal transduction mechanisms]
      COG3899
      Location:383 → 1400
      COG3899; Predicted ATPase [General function prediction only]
      cd00130
      Location:1636 → 1737
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00069
      Location:37 → 288
      Pkinase; Protein kinase domain
      pfam13191
      Location:380 → 557
      AAA_16; AAA ATPase domain
      cl21453
      Location:42 → 287
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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