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    PAN3 Poly(A) specific ribonuclease subunit PAN3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PAN3provided by FlyBase
    Official Full Name
    Poly(A) specific ribonuclease subunit PAN3provided by FlyBase
    Primary source
    FLYBASE:FBgn0035397
    Locus tag
    Dmel_CG11486
    See related
    AllianceGenome:FB:FBgn0035397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11486; Dmel\CG11486; pan3; Pan3
    Summary
    Predicted to enable poly(A) binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Is expressed in adult brain; adult brain cell body rind; organism; and spermatozoon. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PAN3 in Genome Data Viewer
    Location:
    63A6-63B1; 3-5 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3071133..3090406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3071133..3090406)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 63BC Neighboring gene transfer RNA:Cysteine-GCA 1-1 Neighboring gene Chitinase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. Gerrard DT, et al. PLoS One, 2013. PMID 23826372, Free PMC Article
    2. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article
    3. Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. Raisch T, et al. EMBO J, 2016 May 2. PMID 26968986, Free PMC Article
    4. A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Sgromo A, et al. Nat Commun, 2017 Feb 6. PMID 28165457, Free PMC Article
    5. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Huntzinger E, et al. Nucleic Acids Res, 2013 Jan. PMID 23172285, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAN complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Poly(A) specific ribonuclease subunit PAN3
    Names
    CG11486-PA
    CG11486-PB
    CG11486-PC
    CG11486-PD
    CG11486-PF
    CG11486-PG
    CG11486-PH
    CG11486-PJ
    CG11486-PK
    CG11486-PL
    CG11486-PM
    CG11486-PN
    CG11486-PO
    CG11486-PP
    CG11486-PQ
    CG11486-PR
    PAN3-PA
    PAN3-PB
    PAN3-PC
    PAN3-PD
    PAN3-PF
    PAN3-PG
    PAN3-PH
    PAN3-PJ
    PAN3-PK
    PAN3-PL
    PAN3-PM
    PAN3-PN
    PAN3-PO
    PAN3-PP
    PAN3-PQ
    PAN3-PR
    polyA-nuclease related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3071133..3090406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167977.3 → NP_728799.1  Poly(A) specific ribonuclease subunit PAN3, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Related
      FBpp0072870
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    2. NM_167976.3 → NP_728798.1  Poly(A) specific ribonuclease subunit PAN3, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Related
      FBpp0072868
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    3. NM_139510.4 → NP_647767.1  Poly(A) specific ribonuclease subunit PAN3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RR8
      UniProtKB/TrEMBL
      D3DMN9
      Related
      FBpp0072861
      Conserved Domains (2) summary
      cd00180
      Location:406 → 570
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:245 → 284
      DUF4797; Domain of unknown function (DUF4797)

    4. NM_001104017.2 → NP_001097487.1  Poly(A) specific ribonuclease subunit PAN3, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q8IRE7
      Conserved Domains (2) summary
      cd00180
      Location:373 → 537
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:212 → 251
      DUF4797; Domain of unknown function (DUF4797)

    5. NM_206261.3 → NP_995983.1  Poly(A) specific ribonuclease subunit PAN3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    6. NM_206260.3 → NP_995982.1  Poly(A) specific ribonuclease subunit PAN3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    7. NM_167979.3 → NP_728801.1  Poly(A) specific ribonuclease subunit PAN3, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q8IRE7
      Related
      FBpp0072869
      Conserved Domains (2) summary
      cd00180
      Location:373 → 537
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:212 → 251
      DUF4797; Domain of unknown function (DUF4797)

    8. NM_001104018.2 → NP_001097488.1  Poly(A) specific ribonuclease subunit PAN3, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    9. NM_167978.3 → NP_728800.1  Poly(A) specific ribonuclease subunit PAN3, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Related
      FBpp0072871
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    10. NM_167975.3 → NP_728797.1  Poly(A) specific ribonuclease subunit PAN3, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q7KV83
      Related
      FBpp0072862
      Conserved Domains (2) summary
      cd00180
      Location:404 → 568
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:243 → 282
      DUF4797; Domain of unknown function (DUF4797)

    11. NM_167981.2 → NP_728803.2  Poly(A) specific ribonuclease subunit PAN3, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728803.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q8IRE7
      Conserved Domains (2) summary
      cd00180
      Location:373 → 537
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:212 → 251
      DUF4797; Domain of unknown function (DUF4797)

    12. NM_167980.3 → NP_728802.2  Poly(A) specific ribonuclease subunit PAN3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728802.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q9VZV3
      Related
      FBpp0072864
      Conserved Domains (2) summary
      cd00180
      Location:396 → 560
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:235 → 274
      DUF4797; Domain of unknown function (DUF4797)

    13. NM_167983.3 → NP_728805.1  Poly(A) specific ribonuclease subunit PAN3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q9I7T8
      Related
      FBpp0072863
      Conserved Domains (2) summary
      cd00180
      Location:358 → 522
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:197 → 236
      DUF4797; Domain of unknown function (DUF4797)

    14. NM_001104016.2 → NP_001097486.1  Poly(A) specific ribonuclease subunit PAN3, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNJ2, D3DMN9
      Conserved Domains (2) summary
      cd00180
      Location:365 → 529
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:204 → 243
      DUF4797; Domain of unknown function (DUF4797)

    15. NM_167984.3 → NP_728806.1  Poly(A) specific ribonuclease subunit PAN3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q9I7T8
      Related
      FBpp0072865
      Conserved Domains (2) summary
      cd00180
      Location:358 → 522
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:197 → 236
      DUF4797; Domain of unknown function (DUF4797)

    16. NM_167982.3 → NP_728804.1  Poly(A) specific ribonuclease subunit PAN3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMN9, Q9I7T8
      Related
      FBpp0072866
      Conserved Domains (2) summary
      cd00180
      Location:358 → 522
      PKc; Catalytic domain of Protein Kinases
      pfam16051
      Location:197 → 236
      DUF4797; Domain of unknown function (DUF4797)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNJ2 A8JNJ2
    Q7KV83 Q7KV83
    Q8IRE7 Q8IRE7
    Q95RR8.1 Q95RR8
    Q9I7T8 Q9I7T8
    Q9VZV3 Q9VZV3

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