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    mim missing-in-metastasis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768716, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mimprovided by FlyBase
    Official Full Name
    missing-in-metastasisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053558
    Locus tag
    Dmel_CG33558
    See related
    AllianceGenome:FB:FBgn0053558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1E4; CG33352; CG33558; CG9469; Dmel\CG33558; dmim; Dm_2R:10851; Mim; MIM
    Summary
    Enables SH3 domain binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including border follicle cell migration; filopodium assembly; and germ cell migration. Part of protein-containing complex. Is expressed in adult central brain; adult optic lobe; brain; mushroom body; and ventral nerve cord. Used to study intellectual developmental disorder with ocular anomalies and distinctive facial features. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Orthologous to several human genes including MTSS1 (MTSS I-BAR domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See mim in Genome Data Viewer
    Location:
    42E1-42E1; 2-55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6924687..6971637, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2812192..2859142, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Serpin 42De Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Lysine-CTT 1-6 Neighboring gene transfer RNA:Lysine-CTT 1-7 Neighboring gene transfer RNA:Lysine-CTT 1-8 Neighboring gene transfer RNA:Lysine-CTT 1-9 Neighboring gene Chemosensory protein B 42b Neighboring gene Chemosensory protein B 42c Neighboring gene Chemosensory protein B 42a Neighboring gene pickpocket 25 Neighboring gene long non-coding RNA:CR44170 Neighboring gene Cytochrome P450 6u1 Neighboring gene UFM1 specific peptidase 1 Neighboring gene visceral mesodermal armadillo-repeats

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. Huang Y, et al. Am J Hum Genet, 2022 Oct 6. PMID 36067766, Free PMC Article
    2. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article
    3. Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis. Biton T, et al. J Cell Biol, 2023 Nov 6. PMID 37707500, Free PMC Article
    4. I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. Quinones GA, et al. J Cell Biol, 2010 Apr 19. PMID 20385776, Free PMC Article
    5. Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Reed SC, et al. Cell Microbiol, 2012 Apr. PMID 22188208, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c6947314-6947121 mobile_element_type = transposon:INE-1{}2997
    • Loc: c6948972-6948454 mobile_element_type = transposon:INE-1{}2998

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    missing-in-metastasis
    Names
    CG33558-PB
    CG33558-PC
    CG33558-PD
    CG33558-PE
    CG33558-PF
    CG33558-PG
    CG33558-PH
    CG33558-PI
    CG33558-PJ
    CG33558-PK
    CG33558-PL
    CG33558-PM
    CG33558-PN
    anon-fast-evolving-1E4
    mim-PB
    mim-PC
    mim-PD
    mim-PE
    mim-PF
    mim-PG
    mim-PH
    mim-PI
    mim-PJ
    mim-PK
    mim-PL
    mim-PM
    mim-PN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6924687..6971637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273819.1 → NP_001260748.1  missing-in-metastasis, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEE8
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    2. NM_001201941.2 → NP_001188870.1  missing-in-metastasis, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCQ4
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    3. NM_001014500.3 → NP_001014500.2  missing-in-metastasis, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6S0
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    4. NM_001169597.2 → NP_001163068.1  missing-in-metastasis, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDW8, E1JGY9
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    5. NM_001103735.3 → NP_001097205.1  missing-in-metastasis, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY50
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    6. NM_001201940.3 → NP_001188869.1  missing-in-metastasis, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCZ8
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    7. NM_001273818.1 → NP_001260747.1  missing-in-metastasis, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEU9
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    8. NM_001273820.1 → NP_001260749.1  missing-in-metastasis, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KED3
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    9. NM_001201939.3 → NP_001188868.1  missing-in-metastasis, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD47, B6IDW8
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    10. NM_001259228.2 → NP_001246157.1  missing-in-metastasis, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K822
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    11. NM_001273821.1 → NP_001260750.1  missing-in-metastasis, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEK0
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    12. NM_001259230.2 → NP_001246159.1  missing-in-metastasis, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7T1
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    13. NM_001259229.2 → NP_001246158.1  missing-in-metastasis, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7H4
      Conserved Domains (1) summary
      cd07643
      Location:7 → 238
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCQ4 A0A0B4JCQ4
    A0A0B4JCZ8 A0A0B4JCZ8
    A0A0B4JD47 A0A0B4JD47
    A0A0B4K7H4 A0A0B4K7H4
    A0A0B4K7T1 A0A0B4K7T1
    A0A0B4K822 A0A0B4K822
    A0A0B4KED3 A0A0B4KED3
    A0A0B4KEE8 A0A0B4KEE8
    A0A0B4KEK0 A0A0B4KEK0
    A0A0B4KEU9 A0A0B4KEU9
    A1Z6S0 A1Z6S0
    A8DY50 A8DY50
    E1JGY9 E1JGY9

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