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    CCT1 Chaperonin containing TCP1 subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCT1provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0003676
    Locus tag
    Dmel_CG5374
    See related
    AllianceGenome:FB:FBgn0003676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH05123; cct1; Cct1; CG5374; Dmel\CG5374; gh05123; T-cp1; T-CP1; T-cpl; Tcp-1; TCP-1alpha; tcp1; Tcp1; Tcp1-alpha; TCP1-alpha; Tcp1-like; TCP1alpha; TCPA_DROME
    Summary
    Predicted to enable unfolded protein binding activity. Involved in follicle cell of egg chamber development. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT1 in Genome Data Viewer
    Location:
    94B1-94B1; 3-75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22489105..22491439, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18314827..18317161, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein Neighboring gene testis-enriched HMG-box-containing protein 1 Neighboring gene testis-enriched HMG-box-containing protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila melanogaster gene encodes a protein homologous to the mouse t complex polypeptide 1. Ursic D, et al. Gene, 1988 Sep 7. PMID 3146529
    2. Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles. Papatsenko D, et al. PLoS Biol, 2011 Jan 25. PMID 21283609, Free PMC Article
    3. CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, et al. Nat Commun, 2016 Dec 8. PMID 27929117, Free PMC Article
    4. Early evolution of the bilateria. Hausdorf B. Syst Biol, 2000 Mar. PMID 12116476
    5. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation
      Title: CCT complex restricts neuropathogenic protein aggregation via autophagy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 1
    Names
    CCT1-PA
    CCT1-PB
    CG5374-PA
    CG5374-PB
    T-complex 1
    Tcp1-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22489105..22491439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170016.2 → NP_732748.1  chaperonin containing TCP1 subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732748.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12613, Q9VCZ6
      UniProtKB/TrEMBL
      A4V391
      Related
      FBpp0083683
      Conserved Domains (1) summary
      cd03335
      Location:12 → 538
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

    2. NM_079726.4 → NP_524450.2  chaperonin containing TCP1 subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524450.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12613, Q9VCZ6
      UniProtKB/TrEMBL
      A4V391
      Related
      FBpp0083684
      Conserved Domains (1) summary
      cd03335
      Location:12 → 538
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V391 A4V391
    P12613.2 P12613

    Gene LinkOut

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