Cdk7 Cyclin-dependent kinase 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk7provided by FlyBase
Official Full Name: Cyclin-dependent kinase 7provided by FlyBase
Primary source: FLYBASE:FBgn0263237
Locus tag: Dmel_CG3319
See related: AllianceGenome:FB:FBgn0263237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CD 7; cdk-7; cdk7; CDK7; CG3319; dCdk7; Dmcdk7; DmCdk7; DmCDK7; Dmel\CG3319; DmMo15; DmMO15; Mo15; p40[MO15]
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including RNA polymerase II promoter clearance; mitotic cell cycle; and negative regulation of hippo signaling. Located in cytoplasm; nucleolus; and nucleoplasm. Part of transcription factor TFIIH holo complex. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4F4-4F4; 1-11 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5307465..5308983, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5201498..5203016, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Title: Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Genetic and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH. Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II.
Title: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.
CDK7 is required for the mitochondrial localization of Hid and induction of apoptosis.
Title: CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid.
The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Title: Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation.
Cdk7 is required for full activation of Drosophila heat-shock genes and RNA polymerase II phosphorylation in vivo.
Title: Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II promoter clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of carboxy-terminal domain protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH holo complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH holo complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIIH holo complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cyclin-dependent kinase 7

Names: CG3319-PA; Cdk7-PA; Mo15

NP_511044.1

EC 2.7.11.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5307465..5308983 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078489.3 → NP_511044.1 Cyclin-dependent kinase 7 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511044.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24216

Related

FBpp0070723

Conserved Domains (2) summary

PTZ00024
Location:6 → 308

PTZ00024; cyclin-dependent protein kinase; Provisional

cd07841
Location:11 → 308

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7