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    Fip1 Factor interacting with poly(A) polymerase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fip1provided by FlyBase
    Official Full Name
    Factor interacting with poly(A) polymerase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037255
    Locus tag
    Dmel_CG1078
    See related
    AllianceGenome:FB:FBgn0037255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.35; CG1078; clone 1.35; dFip1; Dmel\CG1078; FIP1
    Summary
    Enables myosin binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fip1 in Genome Data Viewer
    Location:
    82B3-82B4; 3-47.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4485008..4487677)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (310730..313399)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sterile affecting ciliogenesis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR31526

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide survey of RS domain proteins. Boucher L, et al. RNA, 2001 Dec. PMID 11780626, Free PMC Article
    2. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article
    3. 3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors. Sabath I, et al. RNA, 2013 Dec. PMID 24145821, Free PMC Article
    4. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article
    5. A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Wagner EJ, et al. Mol Cell, 2007 Nov 30. PMID 18042462

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    factor interacting with poly(A) polymerase 1
    Names
    CG1078-PA
    Fip1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4485008..4487677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141219.2 → NP_649476.1  factor interacting with poly(A) polymerase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN31
      Related
      FBpp0078568
      Conserved Domains (2) summary
      pfam01846
      Location:530 → 579
      FF; FF domain
      pfam05182
      Location:219 → 261
      Fip1; Fip1 motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN31 Q9VN31

    Gene LinkOut

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