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    sip2 septin interacting protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sip2provided by FlyBase
    Official Full Name
    septin interacting protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031878
    Locus tag
    Dmel_CG9188
    See related
    AllianceGenome:FB:FBgn0031878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9188; Dmel\CG9188; fip; FIP; SIP2
    Summary
    Involved in mitotic cytokinesis and protein localization. Colocalizes with microtubule plus-end; midbody; and mitotic spindle midzone. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sip2 in Genome Data Viewer
    Location:
    27C7-27C7; 2-23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6961516..6964074, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6961516..6964074, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Stromalin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 1 Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene Coproporphyrinogen oxidase Neighboring gene Small ubiquitin like modifier

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fascetto interacting protein ensures proper cytokinesis and ploidy. Swider ZT, et al. Mol Biol Cell, 2019 Apr 1. PMID 30726162, Free PMC Article
    2. Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. Shih HP, et al. J Cell Sci, 2002 Mar 15. PMID 11884525
    3. Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Lowery LA, et al. Genetics, 2010 Aug. PMID 20498300, Free PMC Article
    4. Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. Palgi M, et al. BMC Genomics, 2012 Apr 11. PMID 22494833, Free PMC Article
    5. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    septin interacting protein 2
    Names
    CG9188-PA
    CG9188-PB
    CG9188-PC
    CG9188-PD
    CG9188-PE
    feo interacting protein
    sip2-PA
    sip2-PB
    sip2-PC
    sip2-PD
    sip2-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6961516..6964074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135246.3 → NP_609090.2  septin interacting protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609090.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV39, Q8SZ50, Q9VM57
      Related
      FBpp0078985

    2. NM_164722.2 → NP_723234.2  septin interacting protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723234.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV39, Q7KTL5, Q8SZ50
      Related
      FBpp0078986

    3. NM_164723.1 → NP_723235.2  septin interacting protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723235.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F7VJV6, Q7KTL4
      Related
      FBpp0078987, FBtr0079359

    4. NM_164724.1 → NP_723236.1  septin interacting protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV39, Q8SZ50, Q9VM57
      Related
      FBpp0078988, FBtr0079360

    5. NM_164725.3 → NP_723237.1  septin interacting protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV39, Q8SZ50, Q9VM57
      Related
      FBpp0078989
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTL4 Q7KTL4
    Q7KTL5 Q7KTL5
    Q8SZ50 Q8SZ50
    Q9VM57 Q9VM57

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