RpL5 Ribosomal protein L5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RpL5provided by FlyBase
Official Full Name: Ribosomal protein L5provided by FlyBase
Primary source: FLYBASE:FBgn0064225
Locus tag: Dmel_CG17489
See related: AllianceGenome:FB:FBgn0064225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17489; Dmel\CG17489; dRPL5; E-2d; L18; L5; M(2)40B; Rp L5; Rpl5; RPL5; yip6
Summary: A structural constituent of ribosome. Predicted to be involved in ribosomal large subunit assembly. Located in cytosolic ribosome. Is expressed in adult head; adult heart; organism; and ovary. Used to study intrinsic cardiomyopathy. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22532279..22536884, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22425011..22429616, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

eclipse might be a novel ribosome associated protein interacting with dRPL5
Title: Drosophila Ecp is a novel ribosome associated protein interacting with dRPL5.
RpL5, located in the centric heterochromatin of chromosome 2, was analyzed genetically.
Title: Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables 5S rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 5S rRNA binding	IEA Inferred from Electronic Annotation more info
enables 5S rRNA binding	NAS Non-traceable Author Statement more info	PubMed
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	HDA more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed
enables structural constituent of ribosome	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	TAS Traceable Author Statement more info	PubMed
involved_in ribosomal large subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
part_of cytosolic large ribosomal subunit	TAS Traceable Author Statement more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	IEA Inferred from Electronic Annotation more info

Names: CG17489-PA; CG17489-PB; CG17489-PG; CG17489-PH; RpL5-PA; RpL5-PB; RpL5-PG; RpL5-PH; enhancer on chromosome 2, complementation group d; yippee interacting protein 6

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The following sections contain reference sequences that belong to a specific genome build. Explain