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    wwk white walker [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wwkprovided by FlyBase
    Official Full Name
    white walkerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028879
    Locus tag
    Dmel_CG15270
    See related
    AllianceGenome:FB:FBgn0028879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS04929.1; CG15270; Dmel\CG15270
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Involved in detection of cold stimulus involved in thermoception and detection of temperature stimulus involved in sensory perception of pain. Predicted to be active in plasma membrane. Is expressed in adult head; central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human ANO8 (anoctamin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wwk in Genome Data Viewer
    Location:
    35C1-35C2; 2-51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15074776..15096915)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15074776..15096915)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II elongation factor Neighboring gene sisters on the loose Neighboring gene vasa Neighboring gene vasa intronic gene Neighboring gene uncharacterized protein Neighboring gene shuttle craft

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. St Laurent G, et al. Nat Struct Mol Biol, 2013 Nov. PMID 24077224
    2. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila. Himmel NJ, et al. Elife, 2023 Jan 23. PMID 36688373, Free PMC Article
    3. Identification of a genetic network for an ecologically relevant behavioural phenotype in Drosophila melanogaster. Zhang W, et al. Mol Ecol, 2020 Feb. PMID 31867742
    4. Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. de Wit E, et al. Genome Res, 2005 Sep. PMID 16109969, Free PMC Article
    5. Deciphering the DNA code for the function of the Drosophila polydactyl zinc finger protein Suppressor of Hairy-wing. Baxley RM, et al. Nucleic Acids Res, 2017 May 5. PMID 28158673, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in detection of cold stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    white walker
    Names
    Axs-like
    CG15270-PA
    CG15270-PB
    CG15270-PC
    CG15270-PD
    CG15270-PE
    CG15270-PF
    wwk-PA
    wwk-PB
    wwk-PC
    wwk-PD
    wwk-PE
    wwk-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15074776..15096915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259105.1 → NP_001246034.1  white walker, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX9
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 780
      Anoctamin; Calcium-activated chloride channel

    2. NM_135894.3 → NP_609738.1  white walker, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609738.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V416
      Related
      FBpp0080263
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 758
      Anoctamin; Calcium-activated chloride channel

    3. NM_205997.2 → NP_995719.1  white walker, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT76
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 758
      Anoctamin; Calcium-activated chloride channel

    4. NM_001273530.1 → NP_001260459.1  white walker, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX9
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 780
      Anoctamin; Calcium-activated chloride channel

    5. NM_001299023.1 → NP_001285952.1  white walker, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9Y1
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 758
      Anoctamin; Calcium-activated chloride channel

    6. NM_001299022.1 → NP_001285951.1  white walker, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JE80
      Conserved Domains (1) summary
      pfam04547
      Location:289 → 758
      Anoctamin; Calcium-activated chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCX9 M9PCX9
    Q7KT76 Q7KT76
    Q8MQM3 Q8MQM3
    Q9V416 Q9V416
    X2J9Y1 X2J9Y1
    X2JE80 X2JE80

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