Arr2 Arrestin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arr2provided by FlyBase
Official Full Name: Arrestin 2provided by FlyBase
Primary source: FLYBASE:FBgn0000121
Locus tag: Dmel_CG5962
See related: AllianceGenome:FB:FBgn0000121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 49; AH; arr; Arr; Arr-2; arr2; ARR2; ArrB; ArrB-ml; Beta-Arrestin; CG5962; DAII; DmArrestin-2; Dmel\CG5962; Dro.-Arr.II; PRI
Summary: Predicted to enable G protein-coupled receptor binding activity. Involved in several processes, including negative regulation of G protein-coupled receptor signaling pathway; photoreceptor cell maintenance; and sensory perception of smell. Located in subrhabdomeral cisterna. Is expressed in several structures, including adult head; compound sense organ; imaginal disc; photoreceptor neurons; and rhabdomere. Used to study sensorineural hearing loss. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66D9-66D9; 3-26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8647261..8648936, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8640361..8642036, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.
Title: The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.
identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development
Title: Pri peptides are mediators of ecdysone for the temporal control of development.
Rapid calcium/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction.
Title: Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.
This study indicated that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx.
Title: Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors.
Findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade.
Title: Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2.
We developed a steady-state stochastic model to interpret the dependence of the PDA on effective light intensity and arrestin content and to help deduce the arrestin to rhodopsin ratio from the sensitivity and PDA data.
Title: Photoreceptor responses of fruitflies with normal and reduced arrestin content studied by simultaneous measurements of visual pigment fluorescence and ERG.
CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2
Title: Role of Ca2+/calmodulin-dependent protein kinase II in Drosophila photoreceptors.
news: beta-arrestin is now identified as a regulator of ubiquination and degradation of the Notch receptor
Title: Receptor regulation: beta-arrestin moves up a notch.
a constitutively active arrestin mutant can both induce agonist-independent internalization and stabilize the agonist-high affinity state of an arrestin-insensitive G protein coupled receptor.
Title: The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization.
data suggest a novel model of arrestin-2 regulation mediated by inositol hexakisphosphate
Title: Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3698 (e-PCR)
- UniSTS:474276

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables opsin binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in subrhabdomeral cisterna	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arrestin 2

Names: 49kD arrestin homolog; Arr2-PA; Arrestin-2; Beta-Arrestin; CG5962-PA; arrestin; arrestin B; arrestin-like protein; arrestin2; phosrestin I; phosrestin-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8647261..8648936 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079252.3 → NP_523976.1 arrestin 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523976.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P19107, Q9VSN6

UniProtKB/TrEMBL

A8E775, Q5BIJ0

Related

FBpp0076326

Conserved Domains (2) summary

smart01017
Location:192 → 350

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:17 → 172

Arrestin_N; Arrestin (or S-antigen), N-terminal domain