mew multiple edematous wings [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mewprovided by FlyBase
Official Full Name: multiple edematous wingsprovided by FlyBase
Primary source: FLYBASE:FBgn0004456
Locus tag: Dmel_CG1771
See related: AllianceGenome:FB:FBgn0004456
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha integrin; alpha-PS1; alpha1Int; alphaPS1; alpha[[PS1]]; aPS1; CG1771; CT5254; Dmel\CG1771; Integrin alpha PS1; ItgaPS1; l(1)G0429; l(1)G0443; Mew; PS1; PS1alpha; PSalpha1
Summary: Enables cell adhesion molecule binding activity; extracellular matrix binding activity; and protein heterodimerization activity. Involved in several processes, including axon development; maintenance of epithelial integrity, open tracheal system; and salivary gland development. Located in several cellular components, including basal plasma membrane; focal adhesion; and lateral plasma membrane. Part of integrin complex. Is expressed in several structures, including embryonic/larval midgut primordium; follicle cell; germ layer; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; junctional epidermolysis bullosa; junctional epidermolysis bullosa with pyloric atresia; and muscular disease. Orthologous to several human genes including ITGA6 (integrin subunit alpha 6) and ITGA7 (integrin subunit alpha 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11E3-11E8; 1-42 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13214409..13258490, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13108442..13152523, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alphaPS1betaPS integrin controls salivary gland migration through Rac1 GTPase which downregulates E-cadherin in proximal and distal gland cells.
Title: Rac1 GTPase acts downstream of αPS1βPS integrin to control collective migration and lumen size in the Drosophila salivary gland.
Data indicate that alphaPS1betaPS integrin receptors regulate the amount and type of Sog fragments available for diffusion in the extracellular space and impact Dpp function during oogenesis and pupal wing development.
Title: alphaPS1betaPS integrin receptors regulate the differential distribution of Sog fragments in polarized epithelia.
interaction with gene encoding moleskin
Title: Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	NAS Non-traceable Author Statement more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal defasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in ectodermal digestive tract morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of epithelial integrity, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of smell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of integrin complex	NAS Non-traceable Author Statement more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: multiple edematous wings

Names: CG1771-PA; CG1771-PB; CG1771-PC; CG1771-PD; CG1771-PE; CG1771-PF; PS I alpha; PS1 integrin; PS1-Integrin; Position-specific-1 antigen; Position-specific-antigen-1alpha; alpha integrin; alpha-PS1-integrin; alpha1 integrin; alpha1 integrin subunit; alphaPS integrin; alphaPS1; alphaPS1 integrin; alpha[[PS1]] subunit of integrin; integrin; integrin PSII alpha subunit; integrin alpha PS1; integrin alphaPS1; integrin alphaPS1 subunit; mew-PA; mew-PB; mew-PC; mew-PD; mew-PE; mew-PF; multiple edematous wing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13214409..13258490 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078590.3 → NP_511145.2 multiple edematous wings, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511145.2

Status: REVIEWED

UniProtKB/Swiss-Prot

M9PEG3, M9PHG7, M9PJL8, Q24247, Q8SY51, Q9VYF6

Related

FBpp0073563

Conserved Domains (2) summary

smart00191
Location:378 → 428

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:479 → 1006

Integrin_alpha2; Integrin alpha
NM_167354.2 → NP_727679.1 multiple edematous wings, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727679.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24247

Related

FBpp0073562

Conserved Domains (2) summary

smart00191
Location:281 → 331

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:382 → 909

Integrin_alpha2; Integrin alpha
NM_001272574.1 → NP_001259503.1 multiple edematous wings, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259503.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24247

Conserved Domains (2) summary

smart00191
Location:281 → 331

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:382 → 909

Integrin_alpha2; Integrin alpha
NM_001298267.1 → NP_001285196.1 multiple edematous wings, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285196.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JDJ5

Conserved Domains (2) summary

smart00191
Location:378 → 428

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:479 → 1006

Integrin_alpha2; Integrin alpha
NM_001272575.2 → NP_001259504.1 multiple edematous wings, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259504.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24247

Conserved Domains (2) summary

smart00191
Location:387 → 437

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:488 → 1015

Integrin_alpha2; Integrin alpha
NM_001272576.2 → NP_001259505.1 multiple edematous wings, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259505.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24247

Conserved Domains (2) summary

smart00191
Location:290 → 340

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:391 → 918

Integrin_alpha2; Integrin alpha