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    ps pasilla [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44258, updated on 9-Dec-2024

    Summary

    Official Symbol
    psprovided by FlyBase
    Official Full Name
    pasillaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261552
    Locus tag
    Dmel_CG42670
    See related
    AllianceGenome:FB:FBgn0261552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE47781; CG16765; CG16776; CG16777; CG18509; CG42670; cg8144; CG8144; Dmel\CG42670; EP(3)3406; l(3)10615; NOVA1; Pasilla; PS
    Old locus tag
    Dmel_CG16765; Dmel_CG16777
    Summary
    Enables pre-mRNA intronic binding activity. Involved in positive regulation of RNA splicing and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1) and NOVA2 (NOVA alternative splicing regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    85D16-85D17; 3-48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9417940..9455500)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5243662..5281222)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Mannosidase class II a Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene Glutathione S transferase Z1 Neighboring gene Glutathione S transferase Z2

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables pre-mRNA intronic binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    pasilla
    Names
    CG42670-PB
    CG42670-PC
    CG42670-PD
    CG42670-PF
    CG42670-PG
    CG42670-PH
    CG42670-PI
    CG42670-PJ
    CG42670-PK
    CG42670-PL
    CG42670-PM
    CG42670-PN
    CG42670-PO
    CG42670-PP
    CG42670-PQ
    CG42670-PR
    CG42670-PS
    CG42670-PT
    lethal (3) 10615
    ps-PB
    ps-PC
    ps-PD
    ps-PF
    ps-PG
    ps-PH
    ps-PI
    ps-PJ
    ps-PK
    ps-PL
    ps-PM
    ps-PN
    ps-PO
    ps-PP
    ps-PQ
    ps-PR
    ps-PS
    ps-PT

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9417940..9455500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202270.2 → NP_001189199.1  pasilla, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:488 → 551
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:67 → 132
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    2. NM_001043227.2 → NP_001036692.1  pasilla, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:488 → 551
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:67 → 132
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    3. NM_001202272.2 → NP_001189201.1  pasilla, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:466 → 529
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:45 → 110
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    4. NM_001202274.2 → NP_001189203.1  pasilla, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:488 → 551
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:67 → 132
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    5. NM_169280.4 → NP_731351.3  pasilla, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731351.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:488 → 551
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:67 → 132
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    6. NM_001043230.3 → NP_001036695.1  pasilla, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:466 → 529
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:45 → 110
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    7. NM_001202273.2 → NP_001189202.1  pasilla, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:466 → 529
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:45 → 110
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    8. NM_169281.4 → NP_731352.3  pasilla, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731352.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:488 → 551
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:67 → 132
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    9. NM_001275486.1 → NP_001262415.1  pasilla, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JCX5, A0A0B4KFY5, A0A0B4KGY6, A0A0B4LGY5, A0A0B4LI06, Q0KI94, Q0KI96, Q8INP0, Q8T4D1, Q9GNC8, Q9GQN3, Q9GQN4, Q9VHD4, Q9VHD6
      Conserved Domains (3) summary
      cd09031
      Location:694 → 762
      KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
      cd22435
      Location:274 → 345
      KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
      cd22436
      Location:367 → 436
      KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
    10. NM_001300324.1 → NP_001287253.1  pasilla, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:532 → 595
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:111 → 176
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    11. NM_169283.2 → NP_731354.1  pasilla, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWM9
      Related
      FBpp0081515
      Conserved Domains (1) summary
      cd02396
      Location:34 → 99
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    12. NM_001043232.1 → NP_001036697.1  pasilla, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:455 → 518
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:34 → 99
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    13. NM_001275485.1 → NP_001262414.1  pasilla, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:433 → 496
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:12 → 77
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    14. NM_001300323.1 → NP_001287252.1  pasilla, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023UKB8
      Conserved Domains (2) summary
      cd00105
      Location:510 → 573
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:89 → 154
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    15. NM_001043226.1 → NP_001036691.1  pasilla, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWM9
      Conserved Domains (1) summary
      cd02396
      Location:78 → 143
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    16. NM_001202271.2 → NP_001189200.1  pasilla, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCX5
      Conserved Domains (2) summary
      cd00105
      Location:674 → 737
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:253 → 318
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    17. NM_169284.2 → NP_731355.1  pasilla, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGS7
      Related
      FBpp0081516
      Conserved Domains (2) summary
      cd00105
      Location:499 → 562
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:78 → 143
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    18. NM_169285.3 → NP_731356.1  pasilla, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGS7
      Related
      FBpp0081517
      Conserved Domains (2) summary
      cd00105
      Location:477 → 540
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:56 → 121
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
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