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    RpL21 Ribosomal protein L21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpL21provided by FlyBase
    Official Full Name
    Ribosomal protein L21provided by FlyBase
    Primary source
    FLYBASE:FBgn0032987
    Locus tag
    Dmel_CG12775
    See related
    AllianceGenome:FB:FBgn0032987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey18; anon-EST:Posey30; BcDNA:RH06526; CG12775; Dmel\CG12775; L21e; Rp L21; RPL21
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpL21 in Genome Data Viewer
    Location:
    40F6-40F6; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22247111..22247875, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22247111..22247875, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43765 Neighboring gene NUBP iron-sulfur cluster assembly factor, mitochondrial Neighboring gene Tif-IA Neighboring gene Meiosis regulator and mRNA stability factor 1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. Pinnola A, et al. J Biol Chem, 2007 Nov 2. PMID 17827147
    2. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
    3. Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster. Marygold SJ, et al. Genetics, 2005 Feb. PMID 15520262, Free PMC Article
    4. Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins. Funikov SY, et al. Sci Rep, 2020 Jul 17. PMID 32681087, Free PMC Article
    5. Characterization of the Drosophila melanogaster ribosomal proteome. Alonso J, et al. J Proteome Res, 2006 Aug. PMID 16889426

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein L21
    Names
    CG12775-PA
    CG12775-PB
    CG12775-PC
    RpL21-PA
    RpL21-PB
    RpL21-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22247111..22247875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273760.1 → NP_001260689.1  ribosomal protein L21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9M7
      Conserved Domains (1) summary
      PTZ00189
      Location:1 → 159
      PTZ00189; 60S ribosomal protein L21; Provisional

    2. NM_001299204.1 → NP_001286133.1  ribosomal protein L21, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9M7
      Conserved Domains (1) summary
      PTZ00189
      Location:1 → 159
      PTZ00189; 60S ribosomal protein L21; Provisional

    3. NM_136300.3 → NP_610144.1  ribosomal protein L21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9M7
      Related
      FBpp0085314
      Conserved Domains (1) summary
      PTZ00189
      Location:1 → 159
      PTZ00189; 60S ribosomal protein L21; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9M7 Q9V9M7

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