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    CG3961 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40056, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3961provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036821
    Locus tag
    Dmel_CG3961
    See related
    AllianceGenome:FB:FBgn0036821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACSL1; ACSL1/5/6; ACSL5; ACSL5/6; Dmel\CG3961
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; larval imaginal tissue; and sense organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1); ACSL5 (acyl-CoA synthetase long chain family member 5); and ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3961 in Genome Data Viewer
    Location:
    75E3-75E4; 3-45 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18878250..18890483, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18871350..18883583, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3 Neighboring gene Rad9 Neighboring gene UDP-glucose-glycoprotein glucosyltransferase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ninjurin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster. Trindade de Paula M, et al. Oxid Med Cell Longev, 2016. PMID 27579152, Free PMC Article
    2. A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster. Nunes RD, et al. Development, 2023 Oct 15. PMID 37795747, Free PMC Article
    3. Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster. Ejima A, et al. Genetics, 2004 Dec. PMID 15611177, Free PMC Article
    4. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Oba Y, et al. Biosci Biotechnol Biochem, 2005 Apr. PMID 15849423
    5. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3961-PA
    CG3961-PC
    CG3961-PD
    CG3961-PE
    NP_001262024.1
    NP_649067.2
    NP_730369.1
    NP_730370.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18878250..18890483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140810.4 → NP_649067.2  uncharacterized protein Dmel_CG3961, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649067.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R88, Q9VVT8
      Related
      FBpp0074845
      Conserved Domains (1) summary
      cd05927
      Location:130 → 701
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_168781.3 → NP_730369.1  uncharacterized protein Dmel_CG3961, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R88, Q9VVT8
      Related
      FBpp0074844
      Conserved Domains (1) summary
      cd05927
      Location:130 → 701
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. NM_001275095.1 → NP_001262024.1  uncharacterized protein Dmel_CG3961, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX4, Q95R88
      Conserved Domains (1) summary
      cd05927
      Location:92 → 663
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. NM_168782.2 → NP_730370.2  uncharacterized protein Dmel_CG3961, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730370.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCY2, Q95R88
      Conserved Domains (1) summary
      cd05927
      Location:80 → 651
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCY2 E2QCY2
    M9PCX4 M9PCX4
    Q95R88 Q95R88
    Q960G4 Q960G4
    Q9VVT8 Q9VVT8

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