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    wmd wing morphogenesis defect [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wmdprovided by FlyBase
    Official Full Name
    wing morphogenesis defectprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034876
    Locus tag
    Dmel_CG3957
    See related
    AllianceGenome:FB:FBgn0034876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3957; CG3957/wmd; Dmel\CG3957; pter; Unrip; WMD
    Summary
    Predicted to enable RNA binding activity. Involved in imaginal disc-derived wing morphogenesis. Predicted to be part of SMN complex. Is expressed in anterior midgut primordium; head mesoderm; organism; posterior midgut primordium; and trunk mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wmd in Genome Data Viewer
    Location:
    59E3-59E3; 2-103 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23544823..23548151, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19432346..19435674, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59e Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene levy Neighboring gene pita Neighboring gene Death caspase-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy. Borg RM, et al. Neurobiol Dis, 2016 Oct. PMID 27388936
    2. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Liu W, et al. Genetics, 2007 Jun. PMID 17435251, Free PMC Article
    3. Sequence elements in cis influence heterochromatic silencing in trans. Sage BT, et al. Mol Cell Biol, 2005 Jan. PMID 15601858, Free PMC Article
    4. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. Lanfranco M, et al. FEBS Lett, 2017 Nov. PMID 28949413
    5. Disruption of Survival Motor Neuron in Glia Impacts Survival but has no Effect on Neuromuscular Function in Drosophila. Farrugia M, et al. Neuroscience, 2022 May 21. PMID 35314252

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    wing morphogenesis defect
    Names
    CG3957-PA
    CG3957-PB
    pterodactyl
    wmd-PA
    wmd-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23544823..23548151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103966.2 → NP_001097436.1  wing morphogenesis defect, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1N4
      Conserved Domains (2) summary
      cd00200
      Location:12 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:108 → 144
      7WD40; WD40 repeat [structural motif]

    2. NM_137960.3 → NP_611804.1  wing morphogenesis defect, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1N4
      Related
      FBpp0072023
      Conserved Domains (2) summary
      cd00200
      Location:12 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:108 → 144
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1N4 Q9W1N4

    Gene LinkOut

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