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    Hmg-2 High mobility group protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmg-2provided by FlyBase
    Official Full Name
    High mobility group protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026582
    Locus tag
    Dmel_CG9418
    See related
    AllianceGenome:FB:FBgn0026582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD07122; CG9418; Dmel\CG9418; LD07122
    Summary
    Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human HMG20A (high mobility group 20A) and HMG20B (high mobility group 20B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hmg-2 in Genome Data Viewer
    Location:
    57C4-57C4; 2-93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21146203..21147608)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17033708..17035113)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tryptophan-CCA 2-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. Pirooznia SK, et al. PLoS One, 2012. PMID 22848598, Free PMC Article
    2. The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F. Bugga L, et al. Mol Cell Biol, 2009 Jun. PMID 19332563, Free PMC Article
    3. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622
    4. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Coelho DS, et al. Cell Rep, 2013 Nov 14. PMID 24183663, Free PMC Article
    5. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    high mobility group protein 2
    Names
    CG9418-PA
    Hmg-2-PA
    high mobility group protein 1/2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21146203..21147608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137709.4 → NP_611553.1  high mobility group protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2K8
      Related
      FBpp0071501
      Conserved Domains (1) summary
      cd01390
      Location:76 → 141
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2K8 Q9W2K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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