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    Ibf2 Insulator binding factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ibf2provided by FlyBase
    Official Full Name
    Insulator binding factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037669
    Locus tag
    Dmel_CG9740
    See related
    AllianceGenome:FB:FBgn0037669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9740; Dmel\CG9740; Ibf
    Summary
    Enables chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in heterochromatin boundary formation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ibf2 in Genome Data Viewer
    Location:
    85D4-85D6; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9257727..9258501, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5083449..5084223, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Insulator binding factor 1 Neighboring gene ATPase H+ transporting accessory protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing. Fresán U, et al. PLoS Genet, 2020 Aug. PMID 32750047, Free PMC Article
    2. Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function. Cuartero S, et al. EMBO J, 2014 Mar 18. PMID 24502977, Free PMC Article
    3. Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Maksimenko O, et al. Genome Res, 2015 Jan. PMID 25342723, Free PMC Article
    4. Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects : Insect insulator proteins. Pauli T, et al. BMC Genomics, 2016 Nov 3. PMID 27809783, Free PMC Article
    5. In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila. Arzate-Mejía RG, et al. Nat Commun, 2020 Feb 14. PMID 32060283, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin boundary formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulator binding factor 2
    Names
    CG9740-PA
    Ibf2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9257727..9258501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141617.3 → NP_649874.1  insulator binding factor 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHG6
      Related
      FBpp0081464
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHG6 Q9VHG6

    Gene LinkOut

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