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    cpo couch potato [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpoprovided by FlyBase
    Official Full Name
    couch potatoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263995
    Locus tag
    Dmel_CG43738
    See related
    AllianceGenome:FB:FBgn0263995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1824; 3603; 5339; 6015; BcDNA:AT31405; CG12349; CG18434; cg18435; CG18435; CG31243; CG42457; CG43738; Cpo; CPO; Dmel\CG43738; E(sda)N; l(3)01432; l(3)6015; l(3)j4A1; l(3)j4D4; l(3)j7E2; l(3)j9B3; l(3)rJ553; l(3)s2336; Line N; ORE-17
    Old locus tag
    Dmel_CG31243; Dmel_CG42457
    Summary
    Predicted to enable mRNA binding activity. Involved in chemical synaptic transmission; dormancy process; and regulation of hemocyte proliferation. Located in nucleus. Is expressed in several structures, including imaginal disc; midgut; sense organ; sensory nervous system primordium; and sensory neurons. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cpo in Genome Data Viewer
    Location:
    90D1-90E1; 3-61 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17919832..18018892)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13745554..13844614)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Deoxyribonuclease II Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphism in the couch potato gene clines in eastern Australia but is not associated with ovarian dormancy in Drosophila melanogaster. Lee SF, et al. Mol Ecol, 2011 Jul. PMID 21689187
    2. The intensity of selection acting on the couch potato gene--spatial-temporal variation in a diapause cline. Cogni R, et al. Evolution, 2014 Feb. PMID 24303812
    3. Genomic Responses to Climate Change: Making the Most of the Drosophila Model. Rodrigues MF, et al. Front Genet, 2021. PMID 34326859, Free PMC Article
    4. Larval chemosensory projections and invasion of adult afferents in the antennal lobe of Drosophila. Tissot M, et al. J Neurobiol, 1997 Mar. PMID 9058321
    5. An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility. Zonato V, et al. PLoS One, 2016. PMID 27598401, Free PMC Article

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family has been reported
      Title: Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
    2. The results reveal that the downstream cpo SNP does not seem to play any role in diapause induction in European Drosophila populations in contrast to the upstream coding cpo SNP.
      Title: An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility.
    3. There is no evidence for an association between the cpo I462K polymorphism and ovarian dormancy in Australian fruit flies.
      Title: Polymorphism in the couch potato gene clines in eastern Australia but is not associated with ovarian dormancy in Drosophila melanogaster.
    4. variation for the diapause phenotype is caused by a single Lys/Ile substitution in one of the six cpo transcripts
      Title: An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster.
    5. cpo has a role in regulating proper nervous system function, including seizure susceptibility
      Title: Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    couch potato
    Names
    CG43738-PN
    CG43738-PO
    CG43738-PP
    CG43738-PQ
    CG43738-PR
    CG43738-PS
    CG43738-PT
    CG43738-PU
    CG43738-PV
    CG43738-PW
    CG43738-PX
    CG43738-PY
    couchpotato
    cpo-PN
    cpo-PO
    cpo-PP
    cpo-PQ
    cpo-PR
    cpo-PS
    cpo-PT
    cpo-PU
    cpo-PV
    cpo-PW
    cpo-PX
    cpo-PY
    NP_001014631.3
    • non-AUG (CUG) translation initiation
    NP_001014632.3
    • non-AUG (CUG) translation initiation
    NP_001163640.2
    • non-AUG (CUG) translation initiation
    NP_001262688.1
    • non-AUG (CUG) translation initiation
    NP_001262689.1
    • non-AUG (CUG) translation initiation
    NP_001262690.1
    • non-AUG (CUG) translation initiation
    NP_001262691.1
    • non-AUG (CUG) translation initiation
    NP_001262692.1
    • non-AUG (CUG) translation initiation
    NP_524844.6
    • non-AUG (CUG) translation initiation
    NP_732282.6
    • non-AUG (CUG) translation initiation
    NP_732283.5
    • non-AUG (CUG) translation initiation
    NP_732284.5
    • non-AUG (CUG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17919832..18018892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014631.3 → NP_001014631.3  couch potato, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014631.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01617
      Conserved Domains (2) summary
      COG0724
      Location:428 → 526
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 524
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    2. NM_169781.4 → NP_732282.6  couch potato, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732282.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01617
      Conserved Domains (3) summary
      COG0724
      Location:428 → 526
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 524
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
      cl17169
      Location:713 → 737
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001170169.3 → NP_001163640.2  couch potato, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163640.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01617
      Conserved Domains (2) summary
      COG0724
      Location:428 → 526
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 524
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    4. NM_169782.3 → NP_732283.5  couch potato, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732283.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
      UniProtKB/TrEMBL
      A0A0B4KGD8
      Conserved Domains (2) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    5. NM_001275761.1 → NP_001262690.1  couch potato, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHB6
      Conserved Domains (3) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
      cl17169
      Location:712 → 734
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001275762.1 → NP_001262691.1  couch potato, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
      UniProtKB/TrEMBL
      A0A0B4KGD8
      Conserved Domains (2) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    7. NM_001014632.4 → NP_001014632.3  couch potato, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014632.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01617
      Conserved Domains (3) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12245
      Location:712 → 819
      RRM_scw1_like; RNA recognition motif in yeast cell wall integrity protein scw1 and similar proteins
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    8. NM_001275759.1 → NP_001262688.1  couch potato, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGV8
      Conserved Domains (3) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
      cl17169
      Location:712 → 736
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001275763.1 → NP_001262692.1  couch potato, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
      UniProtKB/TrEMBL
      A0A0B4KGD8
      Conserved Domains (2) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    10. NM_080105.4 → NP_524844.6  couch potato, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524844.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
      UniProtKB/TrEMBL
      A0A0B4KGD8
      Conserved Domains (2) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    11. NM_169783.4 → NP_732284.5  couch potato, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732284.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V319, E1JIN7, Q01617, Q59DW5, Q59DW6, Q8IGV9, Q8MQI9, Q9VED9, Q9VEE1
      UniProtKB/TrEMBL
      A0A0B4KGD8
      Conserved Domains (2) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins

    12. NM_001275760.1 → NP_001262689.1  couch potato, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHP4
      Conserved Domains (3) summary
      COG0724
      Location:428 → 525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12684
      Location:441 → 523
      RRM_cpo; RNA recognition motif in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins
      cl17169
      Location:712 → 736
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGD8 A0A0B4KGD8
    A0A0B4KGV8 A0A0B4KGV8
    A0A0B4KHB6 A0A0B4KHB6
    A0A0B4KHP4 A0A0B4KHP4
    Q01617.4 Q01617

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