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    agt O-6-alkylguanine-DNA alkyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agtprovided by FlyBase
    Official Full Name
    O-6-alkylguanine-DNA alkyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024912
    Locus tag
    Dmel_CG1303
    See related
    AllianceGenome:FB:FBgn0024912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Agt; BG:DS00004.10; CG1303; DmAGT; Dmel\CG1303
    Summary
    Enables methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in DNA alkylation repair. Is expressed in organism and wing disc. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See agt in Genome Data Viewer
    Location:
    84A1-84A1; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6658806..6660100, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2485130..2485822, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Argininosuccinate synthase Neighboring gene TBP-associated factor 1 Neighboring gene uncharacterized protein Neighboring gene twisted bristles roughened eye Neighboring gene labial Neighboring gene Ecdysone-dependent gene 84A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. Kooistra R, et al. Nucleic Acids Res, 1999 Apr 15. PMID 10101186, Free PMC Article
    2. Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids. Liénard MA, et al. Proc Natl Acad Sci U S A, 2016 Jul 19. PMID 27357670, Free PMC Article
    3. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". Araripe LO, et al. BMC Evol Biol, 2010 Dec 14. PMID 21144061, Free PMC Article
    4. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
    5. dTcf/Pangolin suppresses growth and tumor formation in Drosophila. Song S, et al. Proc Natl Acad Sci U S A, 2019 Jul 9. PMID 31235567, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-6-alkylguanine-DNA alkyltransferase
    Names
    CG1303-PA
    CG1303-PB
    agt-PA
    agt-PB
    NP_001303422.1
    NP_477366.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6658806..6660100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316493.1 → NP_001303422.1  O-6-alkylguanine-DNA alkyltransferase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76339
      Conserved Domains (2) summary
      COG0350
      Location:22 → 190
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      cl29527
      Location:111 → 189
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...

    2. NM_058018.3 → NP_477366.1  O-6-alkylguanine-DNA alkyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76339
      Related
      FBpp0081195
      Conserved Domains (2) summary
      COG0350
      Location:22 → 190
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      cl29527
      Location:111 → 189
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76339 O76339

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