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    Swim Secreted Wg-interacting molecule [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37537, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Swimprovided by FlyBase
    Official Full Name
    Secreted Wg-interacting moleculeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034709
    Locus tag
    Dmel_CG3074
    See related
    AllianceGenome:FB:FBgn0034709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3074; Dmel\CG3074; dmw; FBgn0034709; swim
    Summary
    Enables Wnt-protein binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Located in egg chorion and extracellular space. Is expressed in several structures, including adult head; epithelium; gut section; imaginal disc; and somatic trunk mesoderm derivative. Orthologous to human TINAG (tubulointerstitial nephritis antigen) and TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Swim in Genome Data Viewer
    Location:
    58C7-58D1; 2-99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22189817..22202671, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18077322..18090176, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 16 Neighboring gene Vacuolar protein sorting 35 Neighboring gene ncRNA Neighboring gene antisense RNA:CR45376 Neighboring gene Alkaline phosphatase 7 Neighboring gene Alkaline phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of Swim secretion and association with extracellular matrix in the Drosophila embryo. Kaltezioti V, et al. Int J Dev Biol, 2022. PMID 34881800
    2. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Mulligan KA, et al. Proc Natl Acad Sci U S A, 2012 Jan 10. PMID 22203956, Free PMC Article
    3. Regulation of Wnt distribution and function by Drosophila glypicans. Waghmare I, et al. J Cell Sci, 2022 Feb 1. PMID 35112708, Free PMC Article
    4. Glypicans shield the Wnt lipid moiety to enable signalling at a distance. McGough IJ, et al. Nature, 2020 Sep. PMID 32699409, Free PMC Article
    5. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables cysteine-type peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in egg chorion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secreted Wg-interacting molecule
    Names
    CG3074-PA
    CG3074-PB
    Swim-PA
    Swim-PB
    dead man walking

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22189817..22202671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137808.3 → NP_611652.2  secreted Wg-interacting molecule, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611652.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWQ7, Q95S79
      Related
      FBpp0071697
      Conserved Domains (3) summary
      cd02620
      Location:188 → 417
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:41 → 83
      Somatomedin_B; Somatomedin B domain
      cl17735
      Location:91 → 126
      VWC; von Willebrand factor type C domain

    2. NM_166519.2 → NP_726176.1  secreted Wg-interacting molecule, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWQ7, Q95S79
      Related
      FBpp0071698
      Conserved Domains (3) summary
      cd02620
      Location:188 → 417
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:41 → 83
      Somatomedin_B; Somatomedin B domain
      cl17735
      Location:91 → 126
      VWC; von Willebrand factor type C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWQ7 Q7JWQ7
    Q95S79 Q95S79

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