Dronc Death regulator Nedd2-like caspase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Droncprovided by FlyBase
Official Full Name: Death regulator Nedd2-like caspaseprovided by FlyBase
Primary source: FLYBASE:FBgn0026404
Locus tag: Dmel_CG8091
See related: AllianceGenome:FB:FBgn0026404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:GreesD6; anon-EST:GressD6; anon-WO0118547.313; caspase-9; CG8090; CG8091; Dmel\CG8091; dronc; DRONC; Dronc/Casp9; Nc; Nc\Dronc
Summary: Enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway and protein homodimerization activity. Involved in several processes, including nervous system development; programmed cell death involved in cell development; and protein processing. Located in cytoplasm; nucleus; and plasma membrane. Part of apoptosome. Is expressed in several structures, including clypeo-labral primordium; cystic bulge; germline cyst; gut section; and salivary gland. Used to study testicular cancer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67D2-67D2; 3-32 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9968479..9971002)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9961579..9964102)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dark and Dronc activation in Drosophila melanogaster.
Title: Dark and Dronc activation in Drosophila melanogaster.
such Egr-induced necrosis depends on the catalytic activity of the initiator caspase Dronc and the input from JNK signaling but is independent of their roles in apoptosis. Further mosaic analysis with mutants of scribble (scrib), suggests that Egr/JNK-mediated apoptosis and necrosis establish a two-layered defense system to inhibit the oncogenic growth of scrib mutant cells
Title: Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.
in developing epithelial thorax, caspase 3 has a role in non-apoptotic cell motility, while Dronc activation regulates myosin levels and delays wound healing
Title: Non-apoptotic function of Drosophila caspase activation in epithelial thorax closure and wound healing.
Dronc plays a dual role that can either initiate DNA damage response or apoptosis.
Title: The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster.
Activation of epidermal Dronc induces TNF-dependent but effector caspase-independent nociceptive sensitization in the absence of UV. In addition, knockdown of Dronc attenuated nociceptive sensitization induced by full-length TNF/Eiger but not by a constitutively soluble form. UV irradiation induced TNF production in both in vitro and in vivo
Title: Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization.
Dronc protein fails to accumulate in epithelial cells with impaired proteasome function suggesting that it is not degraded by the proteasome.
Title: The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila.
e provide evidence that not all of the non-apoptotic functions of Dronc require its catalytic activity. In conclusion, we demonstrate a mechanism whereby Dronc's apoptotic and non-apoptotic activities can be kept silenced in a non-degradative manner through a single ubiquitylation event in living cells.
Title: An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways.
the principal caspase required for the cleavage of Inhibitor of Apoptosis 2 Protein
Title: Independent Proteolytic Activities Control the Stability and Size of Drosophila Inhibitor of Apoptosis 2 Protein.
Findings suggest that the intrinsic properties of initiator caspase Dronc proteinsare responsible, at least in part, for the differing sensitivity of Ld652Y and BM-N to apoptosis induction upon nucleopolyhedroviruses (NPVs) infection.
Title: Cloning and functional characterization of the Lymantria dispar initiator caspase dronc.
that DRONC protein accumulates in "undead" cells due to increased transcription of dronc in these cells
Title: Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables CARD domain binding	ISM Inferred from Sequence Model more info	PubMed
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in zymogen activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of apoptosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death regulator Nedd2-like caspase

Names: CG8091-PA; Caspase-9-like; Dronc-PA; Nedd2-like caspase; caspase-9; dronc; drosophila Caspase-9 homologue; drosophila Nedd2-like caspase; nedd 2-like caspase

NP_524017.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9968479..9971002

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079293.4 → NP_524017.1 death regulator Nedd2-like caspase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524017.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XYF4

Related

FBpp0076076

Conserved Domains (2) summary

cd00032
Location:186 → 443

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd01671
Location:18 → 106

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain