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    WBP4 WW domain binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 11193, updated on 10-Dec-2024

    Summary

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    Official Symbol
    WBP4provided by HGNC
    Official Full Name
    WW domain binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:12739
    See related
    Ensembl:ENSG00000120688 MIM:604981; AllianceGenome:HGNC:12739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP21; NEDHFDB
    Summary
    This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 9.7), fat (RPKM 9.6) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See WBP4 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (41061509..41084006)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (40280657..40303155)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41635645..41658142)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene E74 like ETS transcription factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41567027-41567568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41567569-41568109 Neighboring gene regulator of G protein signaling 17 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5288 Neighboring gene tRNA-Glu (anticodon TTC) 1-2 Neighboring gene microRNA 3168 Neighboring gene RNA, 7SL, cytoplasmic 597, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome. Klippel S, et al. J Biol Chem, 2011 Nov 4. PMID 21917930, Free PMC Article
    2. Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Takahara T, et al. Mol Cell, 2005 Apr 15. PMID 15837427
    3. FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase. Sticht J, et al. Biophys J, 2019 Feb 5. PMID 30558886, Free PMC Article
    4. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. Bedford MT, et al. J Biol Chem, 2000 May 26. PMID 10748127
    5. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). Huang X, et al. J Biol Chem, 2009 Sep 11. PMID 19592703, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase
      Title: FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase.
    2. Biochemical and biophysical analyses revealed that an intrinsically disordered region of FBP21 binds to an extended surface of the C-terminal Sec63 unit of Brr2. Additional contacts in the C-terminal helicase cassette are required for allosteric inhibition of Brr2 helicase activity.
      Title: A new role for FBP21 as regulator of Brr2 helicase activity.
    3. formin-binding protein 21 (FBP21)-tandem-WW domain binding fosters protein recognition in the pre-spliceosome
      Title: Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome.
    4. analysis of the Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)
      Title: Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of WW domain binding protein 4 (formin binding protein 21, WBP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117310

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-binding protein 4
    Names
    WBP-4
    WW domain-containing binding protein 4
    domain-containing binding protein 4
    formin binding protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007187.5 → NP_009118.1  WW domain-binding protein 4

      See identical proteins and their annotated locations for NP_009118.1

      Status: REVIEWED

      Source sequence(s)
      BC108310, BF513662, CD742574
      Consensus CDS
      CCDS9375.1
      UniProtKB/Swiss-Prot
      B7Z4M2, O75554, Q32P29
      UniProtKB/TrEMBL
      B3KMC8
      Related
      ENSP00000368801.3, ENST00000379487.5
      Conserved Domains (2) summary
      COG5104
      Location:128 → 196
      PRP40; Splicing factor [RNA processing and modification]
      pfam06220
      Location:8 → 44
      zf-U1; U1 zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      41061509..41084006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266245.3 → XP_005266302.1  WW domain-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      B3KMC8
      Conserved Domains (2) summary
      pfam06220
      Location:39 → 75
      zf-U1; U1 zinc finger
      cd00201
      Location:200 → 227
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. XM_047430071.1 → XP_047286027.1  WW domain-binding protein 4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      40280657..40303155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374061.1 → XP_054230036.1  WW domain-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      B3KMC8

    2. XM_054374062.1 → XP_054230037.1  WW domain-binding protein 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75554.1 GenPept UniProtKB/Swiss-Prot:O75554

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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