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    TMEM243 transmembrane protein 243 [ Homo sapiens (human) ]

    Gene ID: 79161, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM243provided by HGNC
    Official Full Name
    transmembrane protein 243provided by HGNC
    Primary source
    HGNC:HGNC:21707
    See related
    Ensembl:ENSG00000135185 MIM:616993; AllianceGenome:HGNC:21707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMTRAG; C7orf23; MM-TRAG
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.8), thyroid (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM243 in Genome Data Viewer
    Location:
    7q21.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87196160..87220587, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (88446097..88470238, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86825476..86849903, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901689 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:86758408-86759168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86780839-86781402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86781403-86781964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18343 Neighboring gene DMTF1 antisense RNA 1 Neighboring gene cyclin D binding myb like transcription factor 1 Neighboring gene uncharacterized LOC105375384 Neighboring gene NANOG hESC enhancer GRCh37_chr7:86830979-86831516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18345 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:86959096-86960295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18346 Neighboring gene TP53 target 1 Neighboring gene carnitine O-octanoyltransferase Neighboring gene ATP binding cassette subfamily B member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 243
    Names
    MDR1 and mitochondrial taxol resistance associated
    MDR1- and mitochondrial taxol resistance-associated protein
    transmembrane protein 243, mitochondrial
    transmembrane protein C7orf23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329472.1NP_001316401.1  transmembrane protein 243 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL711214, BC002837, CB993361
      Consensus CDS
      CCDS5602.1
      UniProtKB/Swiss-Prot
      A4D1C6, B2R9I4, D6W5P1, Q9BU79
      Conserved Domains (1) summary
      pfam10856
      Location:1118
      DUF2678; Protein of unknown function (DUF2678)
    2. NM_001329473.2NP_001316402.1  transmembrane protein 243 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC005076, BC002837, BP236768, CB993361
      Consensus CDS
      CCDS5602.1
      UniProtKB/Swiss-Prot
      A4D1C6, B2R9I4, D6W5P1, Q9BU79
      Conserved Domains (1) summary
      pfam10856
      Location:1118
      DUF2678; Protein of unknown function (DUF2678)
    3. NM_001329474.2NP_001316403.1  transmembrane protein 243 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC005076, BC002837, CB993361
      Consensus CDS
      CCDS5602.1
      UniProtKB/Swiss-Prot
      A4D1C6, B2R9I4, D6W5P1, Q9BU79
      Related
      ENSP00000398083.1, ENST00000433078.5
      Conserved Domains (1) summary
      pfam10856
      Location:1118
      DUF2678; Protein of unknown function (DUF2678)
    4. NM_001329475.2NP_001316404.1  transmembrane protein 243 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC005076, BC002837
      Consensus CDS
      CCDS5602.1
      UniProtKB/Swiss-Prot
      A4D1C6, B2R9I4, D6W5P1, Q9BU79
      Conserved Domains (1) summary
      pfam10856
      Location:1118
      DUF2678; Protein of unknown function (DUF2678)
    5. NM_001410901.1NP_001397830.1  transmembrane protein 243 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes the longer isoform (a).
      Source sequence(s)
      AC005076
      Consensus CDS
      CCDS94136.1
      UniProtKB/TrEMBL
      C9JY04
      Related
      ENSP00000407976.1, ENST00000423734.1
    6. NM_024315.4NP_077291.1  transmembrane protein 243 isoform b

      See identical proteins and their annotated locations for NP_077291.1

      Status: VALIDATED

      Source sequence(s)
      AC005076, BC002837
      Consensus CDS
      CCDS5602.1
      UniProtKB/Swiss-Prot
      A4D1C6, B2R9I4, D6W5P1, Q9BU79
      Related
      ENSP00000257637.3, ENST00000257637.8
      Conserved Domains (1) summary
      pfam10856
      Location:1118
      DUF2678; Protein of unknown function (DUF2678)

    RNA

    1. NR_138030.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005076, BC002837, CB993361, DB241717

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      87196160..87220587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250586.4XP_005250643.1  transmembrane protein 243 isoform X1

      See identical proteins and their annotated locations for XP_005250643.1

      UniProtKB/TrEMBL
      C9JY04
      Conserved Domains (1) summary
      pfam10856
      Location:179
      DUF2678; Protein of unknown function (DUF2678)
    2. XM_005250587.5XP_005250644.1  transmembrane protein 243 isoform X1

      See identical proteins and their annotated locations for XP_005250644.1

      UniProtKB/TrEMBL
      C9JY04
      Conserved Domains (1) summary
      pfam10856
      Location:179
      DUF2678; Protein of unknown function (DUF2678)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      88446097..88470238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)