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    CLEC11A C-type lectin domain containing 11A [ Homo sapiens (human) ]

    Gene ID: 6320, updated on 9-Dec-2024

    Summary

    Official Symbol
    CLEC11Aprovided by HGNC
    Official Full Name
    C-type lectin domain containing 11Aprovided by HGNC
    Primary source
    HGNC:HGNC:10576
    See related
    Ensembl:ENSG00000105472 MIM:604713; AllianceGenome:HGNC:10576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P47; SCGF; LSLCL; CLECSF3
    Summary
    This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 36.6), endometrium (RPKM 6.5) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CLEC11A in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50723364..50725708)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (53812175..53814519)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51226621..51228965)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 3 Neighboring gene Sharpr-MPRA regulatory region 12037 Neighboring gene Sharpr-MPRA regulatory region 12891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14994 Neighboring gene chromosome 19 open reading frame 81 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51165023-51165681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51165682-51166339 Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10976 Neighboring gene CRISPRi-validated cis-regulatory element chr19.5690 Neighboring gene GPR32 pseudogene 1 Neighboring gene G protein-coupled receptor 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-type lectin domain family 11 member A
    Names
    C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3
    C-type lectin superfamily member 3
    lymphocyte secreted C-type lectin
    lymphocyte secreted long form of C-type lectin
    osteolectin
    stem cell growth factor
    stem cell growth factor; lymphocyte secreted C-type lectin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002975.3NP_002966.1  C-type lectin domain family 11 member A precursor

      See identical proteins and their annotated locations for NP_002966.1

      Status: REVIEWED

      Source sequence(s)
      AF020044, BQ014793
      Consensus CDS
      CCDS12800.1
      UniProtKB/Swiss-Prot
      B2RAD4, Q9Y240
      UniProtKB/TrEMBL
      Q5U0B9
      Related
      ENSP00000250340.3, ENST00000250340.9
      Conserved Domains (1) summary
      cd03596
      Location:177321
      CLECT_tetranectin_like; C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      50723364..50725708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      53812175..53814519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)