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    GRM3 glutamate metabotropic receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2913, updated on 27-Nov-2024

    Summary

    Official Symbol
    GRM3provided by HGNC
    Official Full Name
    glutamate metabotropic receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4595
    See related
    Ensembl:ENSG00000198822 MIM:601115; AllianceGenome:HGNC:4595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUR3; mGlu3; GPRC1C; MGLUR3
    Summary
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 15.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRM3 in Genome Data Viewer
    Location:
    7q21.11-q21.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (86643909..86864879)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (87893808..88114781)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86273225..86494195)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85053215-85054073 Neighboring gene long intergenic non-protein coding RNA 972 Neighboring gene NANOG hESC enhancer GRCh37_chr7:85260046-85260587 Neighboring gene NANOG hESC enhancer GRCh37_chr7:85315988-85316510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26220 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:85557785-85558332 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:85958016-85958801 Neighboring gene suppressor of cytokine signaling 5 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85969252-85969876 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85969877-85970501 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:86176787-86177986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:86337538-86338062 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:86389511-86390085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26223 Neighboring gene GRM3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578298-86578835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578836-86579372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18340 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene MPRA-validated peak6623 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:86687932-86688432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18342 Neighboring gene MPRA-validated peak6624 silencer Neighboring gene uncharacterized LOC124901689

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of GRM3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables group II metabotropic glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scaffold protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in astrocyte projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    metabotropic glutamate receptor 3
    Names
    glutamate receptor, metabotropic 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000840.3NP_000831.2  metabotropic glutamate receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000831.2

      Status: REVIEWED

      Source sequence(s)
      AC002081, AC004829, BC041407, X77748
      Consensus CDS
      CCDS5600.1
      UniProtKB/Swiss-Prot
      Q14832, Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9
      UniProtKB/TrEMBL
      A4D1D0, A8K5U1
      Related
      ENSP00000355316.2, ENST00000361669.7
      Conserved Domains (4) summary
      cd06375
      Location:37494
      PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor
      pfam00003
      Location:588825
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67469
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:506554
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_001363522.2NP_001350451.1  metabotropic glutamate receptor 3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC002081, BC041407, DC374499, DQ315361
      Consensus CDS
      CCDS87515.1
      Related
      ENSP00000398767.1, ENST00000439827.1
      Conserved Domains (1) summary
      cd06375
      Location:33441
      PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      86643909..86864879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420268.1XP_047276224.1  metabotropic glutamate receptor 3 isoform X2

      UniProtKB/Swiss-Prot
      Q14832, Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9
      UniProtKB/TrEMBL
      A4D1D0
    2. XM_017012073.3XP_016867562.1  metabotropic glutamate receptor 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      87893808..88114781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357999.1XP_054213974.1  metabotropic glutamate receptor 3 isoform X1