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    INHBC inhibin subunit beta C [ Homo sapiens (human) ]

    Gene ID: 3626, updated on 9-Dec-2024

    Summary

    Official Symbol
    INHBCprovided by HGNC
    Official Full Name
    inhibin subunit beta Cprovided by HGNC
    Primary source
    HGNC:HGNC:6068
    See related
    Ensembl:ENSG00000175189 MIM:601233; AllianceGenome:HGNC:6068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IHBC
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
    Expression
    Restricted expression toward liver (RPKM 50.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See INHBC in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57434784..57452062)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57403060..57420351)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57828567..57845845)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene MPRA-validated peak1746 silencer Neighboring gene RNA, U6 small nuclear 879, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4580 Neighboring gene R3HDM2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 358 Neighboring gene uncharacterized LOC124902947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4581 Neighboring gene inhibin subunit beta E Neighboring gene GLI family zinc finger 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog
    Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    inhibin beta C chain
    Names
    activin beta-C chain
    inhibin beta C subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005538.4NP_005529.1  inhibin beta C chain preproprotein

      See identical proteins and their annotated locations for NP_005529.1

      Status: REVIEWED

      Source sequence(s)
      AC022506, BC130324, BP237373, BX105206
      Consensus CDS
      CCDS8938.1
      UniProtKB/Swiss-Prot
      A1L3Y2, P55103
      UniProtKB/TrEMBL
      B2RBW9
      Related
      ENSP00000308716.2, ENST00000309668.3
      Conserved Domains (1) summary
      smart00204
      Location:247352
      TGFB; Transforming growth factor-beta (TGF-beta) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      57434784..57452062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      57403060..57420351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)