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    PAIP1 poly(A) binding protein interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 10605, updated on 9-Dec-2024

    Summary

    Official Symbol
    PAIP1provided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16945
    See related
    Ensembl:ENSG00000172239 MIM:605184; AllianceGenome:HGNC:16945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAIP1 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43526267..43557411, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43778980..43811059, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43526369..43557513, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C5orf34 antisense RNA 1 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene uncharacterized LOC124900190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43521939-43522548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15995 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:43580594-43581340 Neighboring gene NNT antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85301 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:43602630-43602849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15997 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 3 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene Sharpr-MPRA regulatory region 11344 Neighboring gene ribosomal protein L29 pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of poly(A) binding protein interacting protein 1 (PAIP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12360

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of mCRD-mediated mRNA stability complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 1
    Names
    PABC1-interacting protein 1
    PABP-interacting protein 1
    PAIP-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006451.5NP_006442.2  polyadenylate-binding protein-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006442.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC114956, BC015937, DB089732
      Consensus CDS
      CCDS3947.1
      UniProtKB/Swiss-Prot
      A6NKV8, O60455, Q96B61, Q9BS63, Q9H074
      Related
      ENSP00000302768.3, ENST00000306846.8
      Conserved Domains (2) summary
      PRK14951
      Location:35123
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam02854
      Location:160376
      MIF4G; MIF4G domain
    2. NM_182789.4NP_877590.1  polyadenylate-binding protein-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_877590.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC114956, AK308270, BC015937
      Consensus CDS
      CCDS47204.1
      UniProtKB/TrEMBL
      D6REB4
      Related
      ENSP00000387729.2, ENST00000436644.6
      Conserved Domains (2) summary
      pfam07145
      Location:4561
      PAM2; Ataxin-2 C-terminal region
      pfam02854
      Location:81297
      MIF4G; MIF4G domain
    3. NM_183323.3NP_899152.1  polyadenylate-binding protein-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_899152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, resulting in a different 5' UTR and use of a downstream in-frame start codon. Isoform 3 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC114956, BC015937, DB089732
      Consensus CDS
      CCDS3948.1
      UniProtKB/TrEMBL
      D6REB4
      Related
      ENSP00000339622.4, ENST00000338972.8
      Conserved Domains (2) summary
      pfam07145
      Location:1228
      PAM2; Ataxin-2 C-terminal region
      pfam02854
      Location:48264
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      43526267..43557411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      43778980..43811059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)