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    NFIB nuclear factor I B [ Homo sapiens (human) ]

    Gene ID: 4781, updated on 27-Nov-2024

    Summary

    Official Symbol
    NFIBprovided by HGNC
    Official Full Name
    nuclear factor I Bprovided by HGNC
    Primary source
    HGNC:HGNC:7785
    See related
    Ensembl:ENSG00000147862 MIM:600728; AllianceGenome:HGNC:7785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development and regulation of DNA-templated transcription. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NFIB in Genome Data Viewer
    Location:
    9p23-p22.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14081843..14532077, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14091330..14541744, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14081842..14532075, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene 11 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14204487-14204986 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14238163-14238924 Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 8618 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14273817-14274417 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14274418-14275017 Neighboring gene Sharpr-MPRA regulatory region 4176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:14348801-14349300 Neighboring gene NFIB antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:14355781-14356280 Neighboring gene Sharpr-MPRA regulatory region 5074 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:14395820-14396037 Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene Sharpr-MPRA regulatory region 8525 Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14547038-14547640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14597299-14597830 Neighboring gene zinc finger DHHC-type palmitoyltransferase 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14693435-14693935 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14721879-14722818 Neighboring gene cerberus 1, DAN family BMP antagonist

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Macrocephaly, acquired, with impaired intellectual development
    MedGen: C4748993 OMIM: 618286 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior commissure morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation involved in salivary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in club cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in exit from mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glandular epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glial cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hindbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung ciliated cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation involved in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in principal sensory nucleus of trigeminal nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in salivary gland cavitation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type I pneumocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in type II pneumocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cerebellar mossy fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear factor 1 B-type
    Names
    CCAAT-box-binding transcription factor
    TGGCA-binding protein
    nuclear factor 1/B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190737.2NP_001177666.1  nuclear factor 1 B-type isoform 1

      See identical proteins and their annotated locations for NP_001177666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI140312, AL136366, AL441963, BX648845
      Consensus CDS
      CCDS55291.1
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Related
      ENSP00000370340.1, ENST00000380953.6
      Conserved Domains (3) summary
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:209493
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:947
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    2. NM_001190738.2NP_001177667.1  nuclear factor 1 B-type isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK131233, AL136366, AL137017, AL441963
      Consensus CDS
      CCDS55292.1
      UniProtKB/TrEMBL
      A0A0A0MRX8, A0A1B0GWJ4
      Related
      ENSP00000370321.4, ENST00000380934.8
      Conserved Domains (3) summary
      cl00055
      Location:95199
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:235441
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3773
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    3. NM_001282787.2NP_001269716.1  nuclear factor 1 B-type isoform 4

      See identical proteins and their annotated locations for NP_001269716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.
      Source sequence(s)
      AI140312, AL441963, BP372854, BX648416
      Consensus CDS
      CCDS65007.1
      UniProtKB/Swiss-Prot
      O00712
      Related
      ENSP00000442888.1, ENST00000543693.5
      Conserved Domains (1) summary
      pfam00859
      Location:1237
      CTF_NFI; CTF/NF-I family transcription modulation region
    4. NM_001369458.1NP_001356387.1  nuclear factor 1 B-type isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (5).
      Source sequence(s)
      AL136366, AL159169, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Conserved Domains (3) summary
      pfam00859
      Location:231520
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
    5. NM_001369459.1NP_001356388.1  nuclear factor 1 B-type isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL159169, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Conserved Domains (3) summary
      pfam00859
      Location:231511
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
    6. NM_001369460.1NP_001356389.1  nuclear factor 1 B-type isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94389.1
      UniProtKB/TrEMBL
      A0A1B0GWI9, A0A2R8Y7V8
      Related
      ENSP00000496424.1, ENST00000646622.1
      Conserved Domains (3) summary
      pfam00859
      Location:205494
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:65169
      MH1; N-terminal Mad Homology 1 (MH1) domain
    7. NM_001369461.1NP_001356390.1  nuclear factor 1 B-type isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94386.1
      UniProtKB/TrEMBL
      A0A1B0GWI9, Q5VW30
      Related
      ENSP00000380705.3, ENST00000397575.7
      Conserved Domains (3) summary
      pfam00859
      Location:209489
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    8. NM_001369462.1NP_001356391.1  nuclear factor 1 B-type isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL159169, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Conserved Domains (4) summary
      pfam00859
      Location:231438
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl30265
      Location:407497
      PRK09579; multidrug efflux protein; Reviewed
    9. NM_001369463.1NP_001356392.1  nuclear factor 1 B-type isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:205466
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:65169
      MH1; N-terminal Mad Homology 1 (MH1) domain
    10. NM_001369464.1NP_001356393.1  nuclear factor 1 B-type isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94385.1
      UniProtKB/TrEMBL
      A0A1B0GWI9, Q5VW27
      Related
      ENSP00000380709.2, ENST00000397579.6
      Conserved Domains (4) summary
      pfam00859
      Location:209416
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl30265
      Location:385475
      PRK09579; multidrug efflux protein; Reviewed
    11. NM_001369465.1NP_001356394.1  nuclear factor 1 B-type isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:200484
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:138
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
    12. NM_001369466.1NP_001356395.1  nuclear factor 1 B-type isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Related
      ENSP00000490945.1, ENST00000635877.1
      Conserved Domains (4) summary
      pfam00859
      Location:205412
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:65169
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl30265
      Location:381471
      PRK09579; multidrug efflux protein; Reviewed
    13. NM_001369467.1NP_001356396.1  nuclear factor 1 B-type isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94384.1
      UniProtKB/TrEMBL
      A0A1B0GU97, A0A1B0GWI9
      Related
      ENSP00000490020.1, ENST00000637640.1
      Conserved Domains (4) summary
      PRK15127
      Location:376466
      PRK15127; multidrug efflux RND transporter permease subunit AcrB
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:200407
      CTF_NFI; CTF/NF-I family transcription modulation region
    14. NM_001369468.1NP_001356397.1  nuclear factor 1 B-type isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL159169, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:231437
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:3269
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:91195
      MH1; N-terminal Mad Homology 1 (MH1) domain
    15. NM_001369469.1NP_001356398.1  nuclear factor 1 B-type isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Conserved Domains (3) summary
      pfam00859
      Location:161368
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21125
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl30265
      Location:337427
      PRK09579; multidrug efflux protein; Reviewed
    16. NM_001369470.1NP_001356399.1  nuclear factor 1 B-type isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94390.1
      UniProtKB/TrEMBL
      A0A1B0GVN4
      Related
      ENSP00000490588.1, ENST00000636432.1
      Conserved Domains (3) summary
      pfam10524
      Location:343
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:64116
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:130419
      CTF_NFI; CTF/NF-I family transcription modulation region
    17. NM_001369471.1NP_001356400.1  nuclear factor 1 B-type isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:209414
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    18. NM_001369472.1NP_001356401.1  nuclear factor 1 B-type isoform 19

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94388.1
      UniProtKB/TrEMBL
      A0A1B0GWJ4, U3KQE8
      Related
      ENSP00000475813.2, ENST00000606230.2
      Conserved Domains (3) summary
      pfam00859
      Location:205411
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:65169
      MH1; N-terminal Mad Homology 1 (MH1) domain
    19. NM_001369473.1NP_001356402.1  nuclear factor 1 B-type isoform 20

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:205410
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:65169
      MH1; N-terminal Mad Homology 1 (MH1) domain
    20. NM_001369474.1NP_001356403.1  nuclear factor 1 B-type isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:204409
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:642
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:64168
      MH1; N-terminal Mad Homology 1 (MH1) domain
    21. NM_001369475.1NP_001356404.1  nuclear factor 1 B-type isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWI9
      Conserved Domains (4) summary
      pfam00859
      Location:134341
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:68120
      MH1; N-terminal Mad Homology 1 (MH1) domain
      cl30265
      Location:310400
      PRK09579; multidrug efflux protein; Reviewed
    22. NM_001369476.1NP_001356405.1  nuclear factor 1 B-type isoform 23

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94383.1
      UniProtKB/TrEMBL
      A0A1B0GW37, A0A1B0GWJ4
      Related
      ENSP00000490762.1, ENST00000636057.1
      Conserved Domains (3) summary
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:200406
      CTF_NFI; CTF/NF-I family transcription modulation region
    23. NM_001369477.1NP_001356406.1  nuclear factor 1 B-type isoform 24

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      A0A1B0GWJ4
      Conserved Domains (3) summary
      pfam00859
      Location:191396
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    24. NM_001369478.1NP_001356407.1  nuclear factor 1 B-type isoform 25

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Conserved Domains (3) summary
      pfam00859
      Location:130336
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:443
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:64116
      MH1; N-terminal Mad Homology 1 (MH1) domain
    25. NM_001369479.1NP_001356408.1  nuclear factor 1 B-type isoform 26

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Consensus CDS
      CCDS94382.1
      UniProtKB/TrEMBL
      A0A1B0GWB8
      Related
      ENSP00000490864.1, ENST00000636735.1
      Conserved Domains (2) summary
      pfam00859
      Location:30237
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl30265
      Location:206296
      PRK09579; multidrug efflux protein; Reviewed
    26. NM_001369480.1NP_001356409.1  nuclear factor 1 B-type isoform 27

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      Conserved Domains (1) summary
      pfam00859
      Location:30236
      CTF_NFI; CTF/NF-I family transcription modulation region
    27. NM_001369481.1NP_001356410.1  nuclear factor 1 B-type isoform 28

      Status: VALIDATED

      Source sequence(s)
      AL136366
      Consensus CDS
      CCDS94387.1
      UniProtKB/TrEMBL
      A0A0S2Z4H3, Q5W0Y9
      Related
      ENSP00000370308.3, ENST00000380921.3
      Conserved Domains (2) summary
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    28. NM_001429577.1NP_001416506.1  nuclear factor 1 B-type isoform 29

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
      UniProtKB/TrEMBL
      Q5VW26
      Related
      ENSP00000380711.2, ENST00000397581.7
    29. NM_005596.3NP_005587.2  nuclear factor 1 B-type isoform 3

      See identical proteins and their annotated locations for NP_005587.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI140312, AL441963, BC001283, BX648845, DA785516
      Consensus CDS
      CCDS6474.1
      UniProtKB/Swiss-Prot
      G3V1P1, H7BYE8, O00166, O00712, Q12858, Q5VW29, Q63HM5, Q6ZNF9, Q96J45
      UniProtKB/TrEMBL
      A0A1B0GWJ4, Q5VW28
      Related
      ENSP00000370346.3, ENST00000380959.7
      Conserved Domains (3) summary
      pfam00859
      Location:209415
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RNA

    1. NR_161382.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
    2. NR_161383.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
    3. NR_161384.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136366, AL441963
    4. NR_161385.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL441963

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      14081843..14532077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      14091330..14541744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)