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    KLK10 kallikrein related peptidase 10 [ Homo sapiens (human) ]

    Gene ID: 5655, updated on 3-Dec-2024

    Summary

    Official Symbol
    KLK10provided by HGNC
    Official Full Name
    kallikrein related peptidase 10provided by HGNC
    Primary source
    HGNC:HGNC:6358
    See related
    Ensembl:ENSG00000129451 MIM:602673; AllianceGenome:HGNC:6358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NES1; PRSSL1
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KLK10 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51012739..51020097, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54101211..54108579, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51515995..51523353, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51509835-51510334 Neighboring gene kallikrein related peptidase 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51512731-51513231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51528951-51529509 Neighboring gene kallikrein related peptidase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51529510-51530067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51530627-51531183 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51533216-51533447 Neighboring gene kallikrein related peptidase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kallikrein-10
    Names
    breast normal epithelial cell associated serine protease
    kallikrein 10 protein 1
    kallikrein 10 protein 12
    kallikrein 10 protein 13
    kallikrein 10 protein 2
    kallikrein 10 protein 3
    kallikrein 10 protein 4
    kallikrein 10 protein 5
    kallikrein 10 protein 7
    kallikrein 10 protein 8
    kallikrein 10 protein 9
    normal epithelial cell-specific 1
    protease serine-like 1
    NP_001070968.1
    NP_002767.2
    NP_665895.1
    XP_005259118.1
    XP_005259119.1
    XP_006723350.1
    XP_006723352.1
    XP_016882482.1
    XP_047295058.1
    XP_054177453.1
    XP_054177454.1
    XP_054177455.1
    XP_054177456.1
    XP_054177457.1
    XP_054177458.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077500.2NP_001070968.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_001070968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BM830577, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000375681.1, ENST00000391805.5
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_002776.5NP_002767.2  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_002767.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BC002710, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000311746.2, ENST00000309958.7
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_145888.3NP_665895.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_665895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AF024605, AY561635, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000351640.2, ENST00000358789.8
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51012739..51020097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439102.1XP_047295058.1  kallikrein-10 isoform X1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
    2. XM_006723289.4XP_006723352.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_006723352.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_005259061.4XP_005259118.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_005259118.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_006723287.5XP_006723350.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_006723350.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_005259062.4XP_005259119.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_005259119.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    6. XM_017026993.3XP_016882482.1  kallikrein-10 isoform X1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54101211..54108579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321483.1XP_054177458.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5
    2. XM_054321482.1XP_054177457.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5
    3. XM_054321478.1XP_054177453.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5
    4. XM_054321479.1XP_054177454.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5
    5. XM_054321481.1XP_054177456.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5
    6. XM_054321480.1XP_054177455.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6, W8GWD5