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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_031984.1 RefSeqGene
- Range
-
5007..12135
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001002231.3 → NP_001002231.1 kallikrein-2 isoform 2 preproprotein
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC037199, AF188745, AF188747, AK300527
- Consensus CDS
-
CCDS42597.1
- Related
- ENSP00000350748.3, ENST00000358049.8
- Conserved Domains (2) summary
-
- smart00020
Location:24 → 209
- Tryp_SPc; Trypsin-like serine protease
- cd00190
Location:25 → 209
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
-
NM_001256080.2 → NP_001243009.1 kallikrein-2 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC037199, AF188745, AK300549
- Consensus CDS
-
CCDS58675.1
- UniProtKB/Swiss-Prot
-
P20151
- UniProtKB/TrEMBL
-
B4DU77
- Related
- ENSP00000375686.2, ENST00000391810.6
- Conserved Domains (2) summary
-
- smart00020
Location:13 → 151
- Tryp_SPc; Trypsin-like serine protease
- cd00190
Location:16 → 154
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
-
NM_005551.5 → NP_005542.1 kallikrein-2 isoform 1 preproprotein
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC037199, AF188746, AK300527
- Consensus CDS
-
CCDS12808.1
- UniProtKB/Swiss-Prot
- B4DU93, B4DUB0, F5H8L3, P20151, Q15946, Q9UJZ9
- UniProtKB/TrEMBL
-
A0A024R4J4
- Related
- ENSP00000313581.2, ENST00000325321.8
- Conserved Domains (1) summary
-
- cd00190
Location:25 → 256
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
RNA
-
NR_045762.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC037199, AF188745
- Related
-
ENST00000597439.1
-
NR_045763.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses an alternate splice site, compared to variant 1. This variant (5) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC037199, AF188745, AK300527
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000019.10 Reference GRCh38.p14 Primary Assembly
- Range
-
50873439..50880567
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060943.1 Alternate T2T-CHM13v2.0
- Range
-
53963071..53970199
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001002232.2: Suppressed sequence
- Description
- NM_001002232.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.