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    TSPYL2 TSPY like 2 [ Homo sapiens (human) ]

    Gene ID: 64061, updated on 3-Dec-2024

    Summary

    Official Symbol
    TSPYL2provided by HGNC
    Official Full Name
    TSPY like 2provided by HGNC
    Primary source
    HGNC:HGNC:24358
    See related
    Ensembl:ENSG00000184205 MIM:300564; AllianceGenome:HGNC:24358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
    Summary
    This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSPYL2 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53082367..53088540)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52368603..52374776)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53111549..53117722)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene G protein-coupled receptor 173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53122416-53123240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20855 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene Neighboring gene actin gamma 1 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rDNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    testis-specific Y-encoded-like protein 2
    Names
    CASK-interacting nucleosome assembly protein
    CTCL tumor antigen se20-4
    CTCL-associated antigen se20-4
    TSPY-like protein 2
    cell division autoantigen 1
    cutaneous T-cell lymphoma-associated antigen se20-4
    cutaneous T-cell lymphoma-associated tumor antigen se20-4
    differentially expressed nucleolar TGF-beta1 target
    differentially-expressed nucleolar TGF-beta1 target protein
    nuclear protein of 79 kDa
    testis-specific protein Y encoded-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013267.1 RefSeqGene

      Range
      5008..11181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022117.4NP_071400.1  testis-specific Y-encoded-like protein 2

      See identical proteins and their annotated locations for NP_071400.1

      Status: REVIEWED

      Source sequence(s)
      BC024270, DA076199
      Consensus CDS
      CCDS14350.1
      UniProtKB/Swiss-Prot
      O94799, Q96DG7, Q9BZW6, Q9H2G4
      UniProtKB/TrEMBL
      A8K8U7
      Related
      ENSP00000364591.4, ENST00000375442.8
      Conserved Domains (2) summary
      pfam06957
      Location:543604
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      cl08298
      Location:227396
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      53082367..53088540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029727.2XP_016885216.1  testis-specific Y-encoded-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K8U7
    2. XM_017029726.2XP_016885215.1  testis-specific Y-encoded-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K8U7
      Conserved Domains (2) summary
      NF000535
      Location:486660
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl08298
      Location:227440
      NAP; Nucleosome assembly protein (NAP)
    3. XM_006724592.5XP_006724655.1  testis-specific Y-encoded-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K8U7
      Conserved Domains (2) summary
      pfam06957
      Location:543604
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      cl08298
      Location:227396
      NAP; Nucleosome assembly protein (NAP)
    4. XM_047442353.1XP_047298309.1  testis-specific Y-encoded-like protein 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52368603..52374776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327567.1XP_054183542.1  testis-specific Y-encoded-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K8U7
    2. XM_054327566.1XP_054183541.1  testis-specific Y-encoded-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K8U7
    3. XM_054327568.1XP_054183543.1  testis-specific Y-encoded-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K8U7
    4. XM_054327569.1XP_054183544.1  testis-specific Y-encoded-like protein 2 isoform X4